Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases

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Title:	Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases
Authors:	Liu, Ting Sanchez, James F. Chiang, Yi-Ming Oakley, Berl R. Wang, Clay C. C.
Contributors:	化妝品應用與管理系
Keywords:	ASPERGILLUS-NIDULANS BIOSYNTHETIC-PATHWAY CRYSTAL-STRUCTURE METABOLITE SYSTEM
Date:	2014-03
Issue Date:	2015-05-06 21:24:19 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide synthase (NR-PKS) AfoE of the asperfuranone pathway with the SAT domains from 10 other NR-PKSs. The newly created hybrid with the NR-PKS AN3386 is able to accept a longer starter unit in place of the native substrate to create a novel aromatic polyketide in vivo.
Relation:	Organic Letters, v.16 n.6, pp.1676-1679
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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