Protective effects of an aqueous Pericarpium Granati extract against inflammatory damage in mice

doi:10.1016/j.jff.2014.04.022

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標題:	Protective effects of an aqueous Pericarpium Granati extract against inflammatory damage in mice
作者:	Wang, Bor-Sen Leu, Kuen-Lin Huang, Guan-Jhong Yeh, Ching-Fen Tai, Huo-Mu Ho, Wen-Yueh Huang, Ming-Hsing
貢獻者:	生活應用與保健系化粧品應用與管理系
關鍵字:	Pericarpium Granati HPLC Polyphenolic Carrageenan Anti-inflammatory
日期:	2014-07
上傳時間:	2015-05-06 21:24:09 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	The protective effect of an aqueous Pericarpium Granati extract (APG) against carrageenan-induced inflammatory damage in mice was investigated. The results showed that APG displayed radical scavenging, reducing activity, and liposome protection activity in acellular systems. The implementation of an HPLC helped identify polyphenolic components including epicatechin (11.9 mg/g), gallic acid (3.9 mg/g), ellagic acid (2.4 mg/g), ferulic acid (1.0 mg/g), quercetin (0.7 mg/g), and kaempferol (0.5 mg/g). APG administration in the range of 0.25-1.0 g/kg showed a concentration dependent inhibition on inflammatory response in carrageenan induced mice. The anti-inflammatory effects of APG could be related to the suppression of tissue nitric oxide and tumor necrosis factor-alpha, and associated with the reduction of lipid peroxidation and an increase in antioxidant enzyme activities including catalase, superoxide dismutase, and glutathione peroxidase in vivo. The results showed that APG might serve as a natural source of anti-inflammatory and antioxidative compounds in vivo. (C) 2014 Elsevier Ltd. All rights reserved.
關聯:	Journal of Functional Foods, v.9, pp.183-191
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文 [生活保健科技系] 期刊論文

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