Plasma apelin: A novel biomarker for predicting diabetes

doi:10.1016/j.cca.2014.03.030

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 職業安全衛生系(含防災所) > 期刊論文 > Item 310902800/28647

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標題:	Plasma apelin: A novel biomarker for predicting diabetes
作者:	Ma, Wen-Ya Yu, Tse-Ya Wei, Jung-Nan Hung, Chi-Sheng Lin, Mao-Shin Liao, Ying-Jhu Pei, Dee Su, Ching-Chieh Lu, Kuo-Cheng Liu, Pi-Hua Lin, Cheng-Hsin Chuang, Lee-Ming Kao, Hsien-Li Lin, Jou-Wei Chuang, Ya-Ju Li, Hung-Yuan
貢獻者:	職業安全衛生系
關鍵字:	Apelin Predict Diabetes Biomarker
日期:	2014-08
上傳時間:	2015-05-06 21:23:45 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	Background: Apelin regulates insulin sensitivity and secretion in animals. However, whether plasma apelin predicts incident diabetes in humans remains unknown. Methods: We studied a cohort including 447 subjects (148 men, 299 women) without diabetes and followed for an average of 3 y. Diabetes was diagnosed by an oral glucose tolerance test, plasma hemoglobin A1c, and if the subject was taking medications for diabetes. Plasma apelin-12 at baseline was measured with a commercial kit. Results: Plasma apelin concentrations were higher in women than in men at baseline (p = 0.007). During follow-up, 43 subjects developed type 2 diabetes. Higher plasma apelin concentrations were associated with a higher risk of diabetes in men (p = 0.049) but not in women. Plasma apelin predicted incident type 2 diabetes in men (hazard ratio, 2.13, 95% CI 1.29-3.51, p < 0.05), but not in women, adjusted for age, family history of diabetes, hemoglobin A1c, body mass index, hypertension, and HOMA2-IR. Apelin could improve the prediction ability beyond traditional risk factors in men, and the sensitivity and specificity of plasma apelin at 0.9 ng/ml for this prediction were 63.2% and 58.9%, respectively. In men at risk for diabetes (HbA1c 5.7-6.4%, FPG 100-125 mg/dl, or OGIT-2 h-PG 140-199 mg/dl), the risk for developing diabetes was higher in those with higher plasma apelin concentration than in those with lower plasma apelin concentrations (10.6%/year vs. 5.1%/year, p < 0.001). Conclusions: Plasma apelin is a novel biomarker for predicting type 2 diabetes in men. (C) 2014 Elsevier B.V. All rights reserved.
關聯:	Clinica Chimica Acta, v.435, pp.18-23
显示于类别:	[職業安全衛生系(含防災所)] 期刊論文

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