Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28629
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18074/20272 (89%)
造访人次 : 4371429      在线人数 : 1097
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/28629


    標題: Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP-2
    作者: Liao, Alex Chien Hwa
    Kuo, Chia-Cheng
    Huang, Yei-Chung
    Yeh, Chi-Wei
    Hseu, You-Cheng
    Liu, Jer-Yuh
    Hsu, Li-Sung
    貢獻者: 老人服務事業管理系
    關鍵字: bladder cancer
    migration
    matrix metalloproteinase-2
    naringenin
    日期: 2014-09
    上傳時間: 2015-05-06 21:23:06 (UTC+8)
    出版者: Spandidos Publ Ltd
    摘要: Bladder cancer is one of the causes of cancer-related death and has a high mortality rate due to its metastatic ability. Naringenin, a bioactive compound predominantly found in citrus fruits, exhibits several cellular functions, including anti-oxidant, -lipidemia and -cancer abilities. However, the effects of naringenin on bladder cancer cells are yet to be elucidated. The present study investigated the molecular mechanisms underlying the effects of naringenin on the migration of TSGH-8301 bladder cancer cells. Treatment with naringenin at doses ranging between 0 and 300 mu M over a period of 24 h was found to reduce cell viability. Furthermore, zymography and western blot analysis revealed that naringenin reduced the expression of matrix metalloproteinase (MMP)-2 in a dose-dependent manner, and repressed its activity. Naringenin also reduced TSGH-8301 cell migration in a concentration-dependent manner, as evidenced by wound healing and Transwell (R) assays. In addition, naringenin was found to inhibit AKT activity and block the nuclear translocation of nuclear factor x-light-chain-enhancer of activated B cells. In conclusion, the findings of the present study show that naringenin is capable of inhibiting bladder cancer cell migration through the downregulation of the AKT and MMP-2 pathways.
    關聯: Molecular Medicine Reports, v.10 n.3, pp.1531-1536
    显示于类别:[高齡福祉養生管理系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    28629.pdf653KbAdobe PDF621检视/开启
    index.html0KbHTML1724检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈