Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28629
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    標題: Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP-2
    作者: Liao, Alex Chien Hwa
    Kuo, Chia-Cheng
    Huang, Yei-Chung
    Yeh, Chi-Wei
    Hseu, You-Cheng
    Liu, Jer-Yuh
    Hsu, Li-Sung
    貢獻者: 老人服務事業管理系
    關鍵字: bladder cancer
    migration
    matrix metalloproteinase-2
    naringenin
    日期: 2014-09
    上傳時間: 2015-05-06 21:23:06 (UTC+8)
    出版者: Spandidos Publ Ltd
    摘要: Bladder cancer is one of the causes of cancer-related death and has a high mortality rate due to its metastatic ability. Naringenin, a bioactive compound predominantly found in citrus fruits, exhibits several cellular functions, including anti-oxidant, -lipidemia and -cancer abilities. However, the effects of naringenin on bladder cancer cells are yet to be elucidated. The present study investigated the molecular mechanisms underlying the effects of naringenin on the migration of TSGH-8301 bladder cancer cells. Treatment with naringenin at doses ranging between 0 and 300 mu M over a period of 24 h was found to reduce cell viability. Furthermore, zymography and western blot analysis revealed that naringenin reduced the expression of matrix metalloproteinase (MMP)-2 in a dose-dependent manner, and repressed its activity. Naringenin also reduced TSGH-8301 cell migration in a concentration-dependent manner, as evidenced by wound healing and Transwell (R) assays. In addition, naringenin was found to inhibit AKT activity and block the nuclear translocation of nuclear factor x-light-chain-enhancer of activated B cells. In conclusion, the findings of the present study show that naringenin is capable of inhibiting bladder cancer cell migration through the downregulation of the AKT and MMP-2 pathways.
    關聯: Molecular Medicine Reports, v.10 n.3, pp.1531-1536
    显示于类别:[高齡福祉養生管理系] 期刊論文

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