Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28619
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    標題: Measurement of Visceral Fat: Should We Include Retroperitoneal Fat?
    作者: Hung, Chi-Sheng
    Lee, Jen-Kuang
    Yang, Chung-Yi
    Hsieh, Hung-Ren
    Ma, Wen-Ya
    Lin, Mao-Shin
    Liu, Pi-Hua
    Shih, Shyang-Rong
    Liou, Jyh-Ming
    Chuang, Lee-Ming
    Chen, Ming-Fong
    Lin, Jou-Wei
    Wei, Jung-Nan
    Li, Hung-Yuan
    貢獻者: 職業安全衛生系
    關鍵字: METABOLIC SYNDROME
    INSULIN-RESISTANCE
    PORTAL THEORY
    OBESE MEN
    ADIPOSITY
    RISK
    ASSOCIATION
    DEFINITION
    STATEMENT
    PROGRAM
    日期: 2014-11
    上傳時間: 2015-05-06 21:22:45 (UTC+8)
    出版者: Public Library Science
    摘要: Objective: Whether retroperitoneal fat should be included in the measurement of visceral fat remains controversial. We compared the relationships of fat areas in peritoneal, retroperitoneal, and subcutaneous compartments to metabolic syndrome, adipokines, and incident hypertension and diabetes. Methods: We enrolled 432 adult participants (153 men and 279 women) in a community-based cohort study. Computed tomography at the umbilicus level was used to measure the fat areas. Results: Retroperitoneal fat correlated significantly with metabolic syndrome (adjusted odds ratio (OR), 5.651, p < 0.05) and the number of metabolic abnormalities (p < 0.05). Retroperitoneal fat area was significantly associated with blood pressure, plasma glycemic indices, lipid profile, C-reactive protein, adiponectin (r = -0.244, p < 0.05), and leptin (r = 0.323, p < 0.05), but not plasma renin or aldosterone concentrations. During the 2.94 +/- 0.84 years of follow-up, 32 participants developed incident hypertension. Retroperitoneal fat area (hazard ration (HR) 1.62, p = 0.003) and peritoneal fat area (HR 1.62, p = 0.009), but not subcutaneous fat area (p = 0.14) were associated with incident hypertension. Neither retroperitoneal fat area, peritoneal fat area, nor subcutaneous fat areas was associated with incident diabetes after adjustment. Conclusions: Retroperitoneal fat is similar to peritoneal fat, but differs from subcutaneous fat, in terms of its relationship with metabolic syndrome and incident hypertension. Retroperitoneal fat area should be included in the measurement of visceral fat for cardio-metabolic studies in human.
    關聯: Plos One, v.9 n.11, e772355
    显示于类别:[職業安全衛生系(含防災所)] 期刊論文

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