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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28609


    標題: Isobolographic analysis of interaction between nisoxetine- and mepivacaine-induced spinal blockades in rats
    作者: Leung, Yuk-Man
    Chu, Chin-Chen
    Kuo, Chang-Shin
    Chen, Yu-Wen
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: 休閒保健管理系
    關鍵字: nisoxetine
    spinal blockade
    mepivacaine
    isobologram
    日期: 2014-02
    上傳時間: 2015-05-06 21:22:24 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Although nisoxetine has been shown to elicit cutaneous (peripheral) anesthesia, spinal (central) anesthesia with nisoxetine was not exposed. The aim of this study was to examine spinal anesthesia of nisoxetine and its influence on the antinociceptive action of mepivacaine. We compared nisoxetine with an established local anesthetic mepivacaine for spinal anesthesia after rats were intrathecally injected with drugs. The drugs were spinally administered alone as well as in combination, and their potencies were compared via dose-response curves and isobolographic analysis. We showed that nisoxetine, as well as mepivacaine elicited spinal anesthesia in dose-dependent manners. On a 50% effective dose (ED50) basis, the spinal block effect of nisoxetine in motor function, proprioception, and nociception [0.99 (0.91-1.10), 0.85 (0.76-0.95), 0.82 (0.74-0.89)] was more potent (P<0.05) than that of mepivacaine [1.28 (1.21-1.34), 1.14 (1.07-1.22), 0.99 (0.93-1.05)], respectively. Furthermore, the nociceptive/sensory blockade (ED50) was greater than the motor blockade in both nisoxetine and mepivacaine groups (P<0.05). Saline group (vehicle) produced no spinal anesthesia. Coadministration of nisoxetine with mepivacaine displayed an additive effect. Our data reported nisoxetine produced significant anesthesia at spinal level, and additive interaction with the local anesthetic, mepivacaine. Intrathecal nisoxetine elicited more potent spinal anesthesia than mepivacaine.
    關聯: Fundamental & Clinical Pharmacology, v.28 n.1, pp.88-94
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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