Increased Risk of End-Stage Renal Disease in Patients With Renal Cell Carcinoma: A 12-Year Nationwide Follow-Up Study

doi:10.1097/MD.0000000000000052

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 生活保健科技系 > 期刊論文 > Item 310902800/28602

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/28602

標題:	Increased Risk of End-Stage Renal Disease in Patients With Renal Cell Carcinoma: A 12-Year Nationwide Follow-Up Study
作者:	Hung, Peir-Haur Tsai, Hung-Bin Hung, Kuan-Yu Muo, Chih-Hsin Chung, Mu-Chi Chang, Chao-Hsiang Chung, Chi-Jung
貢獻者:	生活應用與保健系
關鍵字:	CHRONIC KIDNEY-DISEASE GLOMERULAR-FILTRATION-RATE NEPHROTIC SYNDROME MEMBRANOUS NEPHROPATHY RADICAL NEPHRECTOMY CORTICAL TUMORS FAILURE GLOMERULONEPHRITIS SURVIVAL DIALYSIS
日期:	2014-08
上傳時間:	2015-05-06 21:22:09 (UTC+8)
出版者:	Lippincott Williams & Wilkins
摘要:	The effect of renal cell carcinoma (RCC) on the risk for end-stage renal disease (ESRD) has not been confirmed. The present population-based study used the claims data from the Taiwan National Health Institutes from 1998 to 2010 to compare the risk for ESRD in patients with and without RCC. The study cohort consisted of 2940 patients who had newly diagnosed with RCC but no history of ESRD; the control cohort consisted of 23,520 matched patients without RCC. Cox proportional hazard regressions were performed to compute ESRD risk after adjusting for possible confounding factors. Kaplan-Meier analysis and the log-rank test were also used to compare patients and controls. A total of 119 patients in the RCC group (incidence rate: 119/2940; 4.05%) and 160 patients in the control group (incidence rate: 160/23,520; 0.68%) were diagnosed with ESRD during the follow-up period. After adjusting for potential confounders, the RCC group had an ESRD hazard ratio (HR) of 5.63 [95% confidence interval (CI): 4.37-7.24] relative to the control group. In addition, among patients with RCC, females (adjusted HR: 6.95, 95% CI: 4.82-10.1) had a higher risk for ESRD than males (adjusted HR: 4.79, 95% CI: 3.376.82). Finally, there were significant joint effects of chronic kidney disease and diabetes on increasing the risk of ESRD in patients with and without RCC (P<0.01). The limitations of this study include the retrospective design and the inability to assess methods of treatment and measure the aggressiveness of RCC. Our data indicates that RCC is an independent risk factor for ESRD, especially in females.
關聯:	Medicine, v.93 n.8, e52
顯示於類別:	[生活保健科技系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	1717	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....