Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

doi:10.1155/2014/983016

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Title:	Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan
Authors:	Jiang, Yi-Der Chuang, Lee-Ming Pei, Dee Lee, Yann-Jinn Wei, Jun-Nan Sung, Fung-Chang Chang, Tien-Jyun
Contributors:	職業安全衛生系
Keywords:	GENOME-WIDE ASSOCIATION HOMEOSTASIS MODEL ASSESSMENT BETA-CELL CLINICAL CHARACTERISTICS E23K POLYMORPHISM YOUTH PREVALENCE K+ CHANNEL FAMILIAL HYPERINSULINISM JAPANESE POPULATION SUR1 ABCC8
Date:	2014
Issue Date:	2015-05-06 21:21:36 (UTC+8)
Publisher:	Hindawi Publishing Corporation
Abstract:	To investigate the role of E23K polymorphism of the KCNJ11 gene on early onset of type 2 diabetes in school-aged children/adolescents in Taiwan, we recruited 38 subjects with type 2 diabetes (ages 18.6 +/- 6.6 years; body mass index percentiles 83.3 +/- 15.4) and 69 normal controls (ages 17.3 +/- 3.8 years; body mass index percentiles 56.7 +/- 29.0) from a national surveillance for childhood/adolescent diabetes in Taiwan. We searched for the E23K polymorphism of the KCNJ11 gene. We found that type 2 diabetic subjects had higher carrier rate of E23K polymorphism of KCNJ11 gene than control subjects (P - 0.044). After adjusting for age, gender, body mass index percentiles, and fasting plasma insulin, the E23K polymorphism contributed to an increased risk for type 2 diabetes (P = 0.047). K23-allele-containing genotypes conferring increased plasma insulin level during OGTT in normal subjects. However, the diabetic subjects with the K23-allele-containing genotypes had lower fasting plasma insulin levels after adjustment of age and BMI percentiles. In conclusion, the E23K variant of the KCNJ11 gene conferred higher susceptibility to type 2 diabetes in children/adolescents. Furthermore, in normal glucose-tolerant children/adolescents, K23 allele carriers had a higher insulin response to oral glucose loading.
Relation:	International Journal of Endocrinology, 983016
Appears in Collections:	[Dept. of Occupational Safety] Periodical Articles

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