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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28582

    標題: Forced Treadmill Running Suppresses Postincisional Pain and Inhibits Upregulation of Substance P and Cytokines in Rat Dorsal Root Ganglion
    作者: Chen, Yu-Wen
    Tzeng, Jann-Inn
    Lin, Min-Fei
    Hung, Ching-Hsia
    Wang, Jhi-Joung
    貢獻者: 食品科技系
    關鍵字: Skin/muscle incision and retraction
    mechanical hypersensitivity
    forced treadmill running
    substance P
    interleukin-1 beta
    日期: 2014-08
    上傳時間: 2015-05-06 21:21:28 (UTC+8)
    出版者: Churchill Livingstone
    摘要: Exercise causes a variety of psychophysical effects (eg, alterations in pain sensation). Tissue injury induces mediator releases in the spinal cord resulting in pain hypersensitivity; however, the contribution of the dorsal root ganglion (DRG) is poorly understood. In this study, we tested if forced treadmill running can attenuate postoperative pain and alter substance P (SP) or proinflammatory cytokine level in the DRG by using a rat model of skin/muscle incision and retraction (SMIR). We evaluated mechanical sensitivity to von Frey stimuli (6 and 15 g) and expression of SP interleukin-1 beta, and interleukin-6 in the DRG of sham-operated sedentary rats, SMIR sedentary rats, sham-operated rats with forced treadmill running, and SMIR rats with forced treadmill running. At postoperative day 8, trained rats ran for 5 days per week for 4 weeks on a treadmill 70 minutes/d with an intensity of 18 m/min. On postoperative day 6, SMIR sedentary rats displayed a significant mechanical hypersensitivity that persisted until postoperative day 35. By comparison, SMIR-operated rats, which received forced treadmill running, exhibited a quick recovery from mechanical hypersensitivity. SMIR sedentary rats showed an upregulation of SP, interleukin-1 beta, and interleukin-6 in the DRG at postoperative days 14 and 28, whereas SMIR-operated rats receiving forced treadmill running reversed this upregulation at postoperative day 28. We concluded that forced treadmill running alleviated persistent postincisional pain caused by SMIR surgery. This appears to be protective against postoperative pain, which probably relates to the downturn in excess SP, interleukin-1 beta, and interleukin-6 in the DRG. Perspective: Controlling the expression of SP, interleukin-6, and interleukin-1 beta in the DRG can help manage postoperative pain. This finding could potentially help clinicians and physical therapists who seek to examine how exercise may attenuate postsurgical pain and its mechanism. (C) 2014 by the American Pain Society
    關聯: Journal of Pain, v.15 n.8, pp.827-834
    Appears in Collections:[ 食品科技系 ] 期刊論文

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