Epinephrine as adjuvant for propranolol produces a marked peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats

doi:10.1016/j.ejphar.2014.06.029

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/28565

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Title:	Epinephrine as adjuvant for propranolol produces a marked peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats
Authors:	Tzeng, Jann-Inn Pan, He-Jia Liu, Kuo-Sheng Chen, Yu-Wen Chen, Yu-Chung Wang, Jhi-Joung
Contributors:	食品科技系藥學系
Keywords:	Co-administration Epinephrine HCl (Pub Chem CID: 5924) (+/-)-Propranolol HCl (Pub Chem CID: 62882) Bupivacaine HCl (Pub Chem CID: 49852290) Subcutaneous injection Cutaneous analgesia
Date:	2014-10
Issue Date:	2015-05-06 21:20:53 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	The aim of this study was to evaluate the effect of epinephrine as additive for propranolol as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we tested the effect of co-administration of epinephrine with propranolol on infiltrative cutaneous analgesia. Bupivacaine, a long-lasting local anesthetic, was used as control. Subcutaneous propranolol and bupivacaine elicited a dose-dependent local anesthetic effect on infiltrative cutaneous analgesia. On the 50% effective dose (ED50) basis, the relative potency was bupivacaine [2.05 (1.95-2.21) mu mol/kg] > propranolol [9.21 (9.08-9.42) mu mol/kg] (P < 0.01 for each comparison). Subcutaneous epinephrine (0.012 mu mol/kg) did not produce cutaneous analgesia. Mixtures of epinephrine (0.012 mu mol/kg) with drugs (propranolol or bupivacaine) at ED50 or ED95, respectively, intensified and prolonged drug action on infiltrative cutaneous analgesia. Intraperitoneal injection of combined drugs (propranolol or bupivacaine) at ED95 with epinephrine (0.012 mu mol/kg) exhibited no cutaneous analgesia. We concluded that propranolol was less potent but produced a similar duration of action when compared to bupivacaine on infiltrative cutaneous analgesia. Epinephrine as adjuvant for propranolol or bupivacaine enhanced the potency and extended the duration of action on infiltrative cutaneous analgesia. (C) 2014 Elsevier B.V. All rights reserved.
Relation:	European Journal of Pharmacology, v.740, pp.565-569
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles [Dept. of Pharmacy] Periodical Articles

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