Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28563
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    Title: Epidemiology and Prognostic Factors of Candidemia in Cancer Patients
    Authors: Tang, Hung-Jen
    Liu, Wei-Lun
    Lin, Hsin-Lan
    Lai, Chih-Cheng
    Contributors: 保健營養系
    Keywords: INVASIVE FUNGAL-INFECTIONS
    CHANGING EPIDEMIOLOGY
    RISK-FACTORS
    SURVEILLANCE
    FLUCONAZOLE
    TAIWAN
    SUSCEPTIBILITY
    CANDIDAEMIA
    MALIGNANCIES
    CANDIDIASIS
    Date: 2014-06
    Issue Date: 2015-05-06 21:20:48 (UTC+8)
    Publisher: Public Library Science
    Abstract: Aim: The study of candidemia in cancer patients has been limited. This retrospective study aims to investigate the epidemiologic characteristics and prognostic factors of candidemia among cancer patients. Materials and Methods: From 2009 to 2012, cancer patients with candidemia were identified at a hospital in Taiwan. The medical records of all patients with bloodstream infections due to Candida species were retrospectively reviewed. Results: During the four-year period, a total of 242 episodes of candidemia were identified among cancer patients. Half of these patients were classified as elderly (>= 65 years old), and more than 95% of the candidemia episodes were classified as healthcare-associated infections. Among the 242 cancer patients with candidemia, head and neck cancer was the most common, followed by gastrointestinal tract and lung cancer. Additionally, most of the patients had variable underlying conditions, such as the presence of CVC (99%) or prior exposure to broad-spectrum antibiotics (93%) and were receiving an immunosuppressant (86%). Overall, C. albicans (n = 132, 54.5%) was the most common pathogen, followed by C. tropicalis (n = 52, 21.5%), C. parapsilosis (n = 38, 15.7%), and C. glabrata (n = 29, 12.0%). Seventeen patients had polycandidal candidemia, and 77 patients had concomitant bacteremia. Approximately one-third of the patients required admission to the intensive care unit (ICU) or mechanical ventilation, and the overall in-hospital mortality was 50.8%. Multivariable analysis showed that the in-hospital mortality was significantly associated with only the non-use of antifungal agents and acute respiratory failure (P<.001). Conclusions: Candidemia can develop in patients with both solid cancer and hematological malignancy, especially for patients with underlying conditions. Overall, the associated morbidity and mortality due to Candidemia remain high. It was also determined that the non-use of antifungal agents and acute respiratory failure conditions were associated with in-hospital mortality.
    Relation: Plos One, v.9 n.6, e99103
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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