End-stage renal disease after hypertensive disorders in pregnancy

doi:10.1016/j.ajog.2013.09.027

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/28561

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28561

Title:	End-stage renal disease after hypertensive disorders in pregnancy
Authors:	Wu, Chia-Chun Chen, Sheng-Hsien Ho, Chung-Han Liang, Fu-Wen Chu, Chin-Chen Wang, Hsien-Yi Lu, Yi-Hua
Contributors:	休閒暨健康管理學院
Keywords:	hypertensive disorder renal disease
Date:	2014-02
Issue Date:	2015-05-06 21:20:44 (UTC+8)
Publisher:	Mosby-Elsevier
Abstract:	OBJECTIVE: The purpose of this study was to determine the long-term postpartum risk of end-stage renal disease in women with hypertensive disorders in pregnancy. Although most women with hypertensive disorders in pregnancy recover after delivery, some may experience acute renal failure. STUDY DESIGN: We searched Taiwan's National Health Insurance Research Database to identify women with hypertensive disorders in pregnancies and deliveries between 1998 and 2002. All cases were followed for a maximum of 11 years (median, 9 years; interquartile range, 7.79-10.02 years) to estimate the incidence of end-stage renal disease; Cox regression analysis that was adjusted for potential confounding was used to determine the relative risk. RESULTS: Of the 13,633 women with hypertensive disorders in pregnancy, 46 experienced end-stage renal disease. Women with hypertensive disorders in pregnancy had a risk of end-stage renal disease that was 10.64 times greater than did women without them (95% confidence interval [CI], 7.53-15.05). The risk was highest in women with a history of preeclampsia superimposed on chronic hypertension (hazard ratio, 44.72; 95% CI, 22.59-88.51). Women with gestational hypertension had a higher risk of end-stage renal disease than did women without hypertensive disorders in pregnancy (hazard ratio, 5.82; 95% CI, 2.15-15.77). CONCLUSION: Women with hypertensive disorders in pregnancy have a higher risk of postpartum end-stage renal disease, regardless of which type of hypertensive disorder they have. Women with a history of hypertensive disorders in pregnancy are encouraged to have regular postpartum checkups, especially of renal function.
Relation:	American Journal of Obstetrics and Gynecology, v.210 n.2, 1470
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles [Dept. of Sports Management] Periodical Articles [Dept. of Recreation and Health-Care Management] Periodical Articles [Dept. of Pharmacy] Periodical Articles

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