Effects of Garlic Oil on Interleukin-6 Mediated Cardiac Hypertrophy in Hypercholesterol-Fed Hamsters

doi:10.4077/CJP.2014.BAC261

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標題:	Effects of Garlic Oil on Interleukin-6 Mediated Cardiac Hypertrophy in Hypercholesterol-Fed Hamsters
作者:	Hsieh, You-Liang Pai, Peiying Ho, Tsung-Jung Chung, Li-Chin Cheng, Yi-Chang Wu, Chieh-Hsi Fan, Ming-Jen Day, Cecilia Hsuan Shen, Chia-Yao Huang, Chih-Yang
貢獻者:	醫務管理系
關鍵字:	garlic oil heart hypercholesterol hypertrophy
日期:	2014-12
上傳時間:	2015-05-06 21:20:26 (UTC+8)
出版者:	Chinese Physiological Soc
摘要:	Hypercholesterol diets are the major causes of cardiac hypertrophy and various cardiac disorders. The purpose of this study is to evaluate the effects of garlic oil on cardiac hypertrophy induced by hypercholesterol diets. Golden Syrian hamsters were fed with 2% cholesterol or 2% cholesterol plus 1% garlic oil for 2 months. Heart architecture changes were measured by hematoxylin-eosin staining and the molecular mechanism was determined by western blotting. Garlic oil reduced whole-heart weight to bone weight ratio, and left ventricle weight to bone weight ratio in the cholesterol-fed group. Moreover, the garlic oil group showed significantly reduced interleukin-6, phosphorylated (p)-extracellular signal-regulated kinase-5, p-mitogen-activated protein kinase-5, calcineurin, nuclear transcription factor of nuclear factor of activated T-cells-3 and p-GATA binding protein 4 when compared with the cholesterol group. However, no changes were observed in gp-130, signal transducer and activator of transcription-3, p-P38 and p-Jun N-terminal kinases protein levels in all groups. The results show that garlic oil may be useful in the treatment of hypertrophy-associated cardiovascular diseases.
關聯:	Chinese Journal of Physiology, v.57 n.6, pp.320-328
顯示於類別:	[醫務管理系(所)] 期刊論文

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