Effects of Garlic Oil on Interleukin-6 Mediated Cardiac Hypertrophy in Hypercholesterol-Fed Hamsters

doi:10.4077/CJP.2014.BAC261

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Title:	Effects of Garlic Oil on Interleukin-6 Mediated Cardiac Hypertrophy in Hypercholesterol-Fed Hamsters
Authors:	Hsieh, You-Liang Pai, Peiying Ho, Tsung-Jung Chung, Li-Chin Cheng, Yi-Chang Wu, Chieh-Hsi Fan, Ming-Jen Day, Cecilia Hsuan Shen, Chia-Yao Huang, Chih-Yang
Contributors:	醫務管理系
Keywords:	garlic oil heart hypercholesterol hypertrophy
Date:	2014-12
Issue Date:	2015-05-06 21:20:26 (UTC+8)
Publisher:	Chinese Physiological Soc
Abstract:	Hypercholesterol diets are the major causes of cardiac hypertrophy and various cardiac disorders. The purpose of this study is to evaluate the effects of garlic oil on cardiac hypertrophy induced by hypercholesterol diets. Golden Syrian hamsters were fed with 2% cholesterol or 2% cholesterol plus 1% garlic oil for 2 months. Heart architecture changes were measured by hematoxylin-eosin staining and the molecular mechanism was determined by western blotting. Garlic oil reduced whole-heart weight to bone weight ratio, and left ventricle weight to bone weight ratio in the cholesterol-fed group. Moreover, the garlic oil group showed significantly reduced interleukin-6, phosphorylated (p)-extracellular signal-regulated kinase-5, p-mitogen-activated protein kinase-5, calcineurin, nuclear transcription factor of nuclear factor of activated T-cells-3 and p-GATA binding protein 4 when compared with the cholesterol group. However, no changes were observed in gp-130, signal transducer and activator of transcription-3, p-P38 and p-Jun N-terminal kinases protein levels in all groups. The results show that garlic oil may be useful in the treatment of hypertrophy-associated cardiovascular diseases.
Relation:	Chinese Journal of Physiology, v.57 n.6, pp.320-328
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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