Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat

doi:10.1111/fcp.12048

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標題:	Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat
作者:	Chen, Yu-Wen Tzeng, Jann-Inn Chen, Ting-Yun Wang, Jhi-Joung Chen, Yu-Chung Hung, Ching-Hsia
貢獻者:	食品科技系
關鍵字:	bupivacaine diphenhydramine dose-response curve infiltrative cutaneous analgesia subcutaneous injection
日期:	2014-08
上傳時間:	2015-05-06 21:20:04 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	Although diphenhydramine has been shown to produce longer duration of spinal block than lidocaine, few studies disclose its skin infiltrative anesthesia when compared with a long-lasting local anesthetic, bupivacaine. The purpose of this study was to investigate whether diphenhydramine elicited cutaneous analgesia in comparison with bupivacaine. After inhibition of cutaneous trunci muscle reflex via subcutaneous injection of drugs in rats, we examined the local anesthetic effect of diphenhydramine and bupivacaine as infiltrative cutaneous analgesia in a dose-dependent fashion. We showed that diphenhydramine, as well as bupivacaine displayed a dose-dependent cutaneous analgesia in response to dorsal cutaneous noxious stimuli. The relative potency (50% effective dose) was bupivacaine (0.023 [0.013-0.035]%) > diphenhydramine (0.078 [0.068-0.091]%; P < 0.001). On an equipotent basis, diphenhydramine had a similar duration of action to bupivacaine. Neither local injection of saline nor intraperitoneal administration of a large dose of diphenhydramine or bupivacaine produced cutaneous analgesia (data not shown). We conclude that diphenhydramine is less potent than bupivacaine at producing cutaneous analgesia. At equipotent doses for infiltrative cutaneous analgesia, the duration of action of diphenhydramine is equal to that of bupivacaine.
關聯:	Fundamental & Clinical Pharmacology, v.28 n.4, pp.439-444
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