Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats

doi:10.1016/j.neulet.2014.05.036

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Title:	Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats
Authors:	Chen, Yu-Wen Tzeng, Jann-Inn Pan, He-Jia Hung, Ching-Hsia Chen, Yu-Chung Wang, Jhi-Joung
Contributors:	食品科技系
Keywords:	Epinephrine Memantine Lidocaine Subcutaneous injection Local anesthetic Cutaneous analgesia
Date:	2014-06
Issue Date:	2015-05-06 21:19:33 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	The purpose of this study was to examine the effect of epinephrine as adjuvant for memantine or lidocaine as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we evaluated the effects of adding epinephrine to memantine or lidocaine on infiltrative cutaneous analgesia. Lidocaine, a known local anesthetic, was used as control. We found that epinephrine, memantine, and lidocaine produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potencies were epinephrine [0.012(0.006-0.020) mu mol] > memantine [4.010 (3.311-4.988) mu mol] > lidocaine [6.177 (5.333-7.218) mu mol] (P<0.05 for each comparison). Mixtures of epinephrine (2.7 nmol or 13.7 nmol) with drugs (memantine or lidocaine) at ED50 or ED95, respectively, enhanced the potency and prolonged the duration of action on infiltrative cutaneous analgesia. Intraperitoneal injection of co-administration of drugs (memantine or lidocaine) at ED95 with epinephrine (13.7 nmol) produced no cutaneous analgesia (data not shown). Epinephrine, memantine, and lidocaine were shown to have local anesthetic effects as infiltrative cutaneous analgesia. Epinephrine increased the duration and potency of memantine and lidocaine as an infiltrative anesthetic. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Relation:	Neuroscience Letters, v.574, pp.59-63
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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