Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats

doi:10.1016/j.neulet.2014.05.036

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/28529

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题名:	Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats
作者:	Chen, Yu-Wen Tzeng, Jann-Inn Pan, He-Jia Hung, Ching-Hsia Chen, Yu-Chung Wang, Jhi-Joung
贡献者:	食品科技系
关键词:	Epinephrine Memantine Lidocaine Subcutaneous injection Local anesthetic Cutaneous analgesia
日期:	2014-06
上传时间:	2015-05-06 21:19:33 (UTC+8)
出版者:	Elsevier Ireland Ltd
摘要:	The purpose of this study was to examine the effect of epinephrine as adjuvant for memantine or lidocaine as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we evaluated the effects of adding epinephrine to memantine or lidocaine on infiltrative cutaneous analgesia. Lidocaine, a known local anesthetic, was used as control. We found that epinephrine, memantine, and lidocaine produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potencies were epinephrine [0.012(0.006-0.020) mu mol] > memantine [4.010 (3.311-4.988) mu mol] > lidocaine [6.177 (5.333-7.218) mu mol] (P<0.05 for each comparison). Mixtures of epinephrine (2.7 nmol or 13.7 nmol) with drugs (memantine or lidocaine) at ED50 or ED95, respectively, enhanced the potency and prolonged the duration of action on infiltrative cutaneous analgesia. Intraperitoneal injection of co-administration of drugs (memantine or lidocaine) at ED95 with epinephrine (13.7 nmol) produced no cutaneous analgesia (data not shown). Epinephrine, memantine, and lidocaine were shown to have local anesthetic effects as infiltrative cutaneous analgesia. Epinephrine increased the duration and potency of memantine and lidocaine as an infiltrative anesthetic. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
關聯:	Neuroscience Letters, v.574, pp.59-63
显示于类别:	[Dept. of Food Science & Technology] Periodical Articles

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