Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28503
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    標題: Antiapoptotic Agent Sphingosine-1-Phosphate Protects Vitrified Murine Ovarian Grafts
    作者: Tsai, Yung-Chieh
    Tzeng, Chii-Ruey
    Wang, Chia-Woei
    Hsu, Ming-I
    Tan, Shun-Jen
    Chen, Chi-Huang
    貢獻者: 通識教育中心
    關鍵字: sphingosine-1-phosphate
    apoptosis
    vitrification
    anti-Mullerian hormone
    日期: 2014-02
    上傳時間: 2015-05-06 21:18:37 (UTC+8)
    出版者: Sage Publications Inc
    摘要: Significant follicle loss from frozen ovarian grafts is unavoidable. The authors evaluated the protective effects of the antiapoptotic agent sphingosine-1-phosphate (S1P) on vitrified ovarian grafts. Three-week-old sexually immature female FVB mice were divided into 4 groups, fresh, control without S1P, 0.5 mmol/L S1P, and 2 mmol/L S1P. The ovaries were pretreated with S1P for 1 hour and then cryopreserved by modified vitrification. The frozen-thawed ovaries were autotransplanted under the back muscles of mice for 10 days. Expression of apoptosis-related genes encoding caspase 3 and c-Myc was analyzed in the vitrified ovaries and 10 days after transplantation using real-time quantitative polymerase chain reaction. To quantify the ovarian reserve, anti-Mullerian hormone (AMH) levels and follicles were measured in the 10-day vitrified ovarian grafts. Caspase 3 and c-Myc messenger RNA did not differ significantly in the 4 groups after vitrification but was significantly upregulated in the control group after transplantation. The AMH levels and primordial follicle pool were significantly higher in the S1P-treated groups than in the control group but lower than that in the fresh group. The S1P protects vitrified ovarian grafts from ischemic reperfusion injury rather than from vitrification-associated process.
    關聯: Reproductive Sciences, v.21 n.2, pp.236-243
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