Age May Not Influence the Outcome of Patients with Severe Sepsis in Intensive Care Units

doi:10.1016/j.ijge.2013.08.004

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/28497

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Title:	Age May Not Influence the Outcome of Patients with Severe Sepsis in Intensive Care Units
Authors:	Chen, Chin-Ming Cheng, Kuo-Chen Chan, Khee-Siang Yu, Wen-Liang
Contributors:	休閒保健管理系
Keywords:	aged intensive care unit multiple organ failure outcomes severe sepsis
Date:	2014-03
Issue Date:	2015-05-06 21:18:26 (UTC+8)
Publisher:	Elsevier Taiwan
Abstract:	Background: This study attempted to determine the association between age and outcome for severe sepsis patients in the intensive care unit (ICU). Methods: From May 2004 through April 2005, we conducted a prospective study of patients with severe sepsis in eight ICUs of Chi-Mei Medical Center. Demographic and clinical information, laboratory results, comorbidities, severity scores, mortality, and lengths of stays for both ICU and hospital were analyzed for older (age > 65 years) and younger adult (age < 65 years) patients. We analyzed the association between age and outcome and the predictors of hospital mortality. Results: Of the 254 patients included, 63.8% were aged >= 65 years. ICU and hospital mortality rates were 50.4% and 55.1%, respectively, for older and younger adult patients. Both groups had similar baseline data, except that the older group had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores, different comorbidities (less active cancer and alcoholism, but higher percentage of cerebral vascular accident) and more neurologic organ failure. Older patients also had higher ICU (54.3% vs. 43.5%, p = 0.097) and hospital mortality (58.0% vs. 50.0%, p = 0.216). Multivariate analyses showed the following predictors of hospital mortality: being female, active cancer, septic shock, acute respiratory distress syndrome, hematological failure, APACHE II scores >25, and inadequate drainage of infection site. Age was not a significant predictor for mortality after adjusting for other factors. Conclusion: In this cohort, age was not an important predictor of mortality in ICU patients with severe sepsis. Physicians should consider other risk factors to improve outcomes in these critically ill aged patients. Copyright (C) 2014, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC, All rights reserved.
Relation:	International Journal of Gerontology, v.8 n.1, pp.22-26
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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