Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XIX. Reactivity of 1-Methyl-2 (1H)-thiopyridone and Its Derivatives

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 1期 (1975) > Item 310902800/28431

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標題:	Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XIX. Reactivity of 1-Methyl-2 (1H)-thiopyridone and Its Derivatives
作者:	Tohoku College of Pharmacy
貢獻者:	私立嘉南藥學專科學校
日期:	1975
上傳時間:	2014-12-26 11:49:18 (UTC+8)
摘要:	Reactivity of 1-methyl-2 (1H)-thiopyridone (I), 1-methyl-2 (1H)-thioquinolone (III), and 2-methyl-1 (2H)-thioisoquinolone (V) was compared with that of the corresponding oxygen compounds, 1-methyl-2 (1H)-pyridone (II), 1-methyl-2 (1H)-quinolone (IV), and 2-methyl-1 (2H)-isoquinolone (VI). In deuteration, I was less reactive than II, III entirely failed to react, and V reacted under a stronger reaction condition than VI. Bromination of I and V was carried out but they did not produce the expected products, although II and VI reacted easily. Grignard reaction as an example of the nucleophilic substitution reactions on III, which was most inactive to the electrophilic substitution reactions, revealed that III is more inactive than IV to this reaction and the yield was not good even under a more drastic condition.
關聯:	嘉南學報, n.1 pp.63-68 轉載 Chemical & pharmaceutical bulletin 21(12), 2607-2612, 1973-12-25
显示于类别:	[藥學系(所)] 期刊論文 [嘉南學報] 1期 (1975)

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