On The Chemical Methylation of Quinones With Methylcobalamin

CNU IR > Chna Nan Annual Bulletin > Vol.1 (1975) > Item 310902800/28428

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Title:	On The Chemical Methylation of Quinones With Methylcobalamin
Authors:	Chau-Yang Chen Takao Kwan
Contributors:	私立嘉南藥學專科學校
Date:	1975
Issue Date:	2014-12-26 11:49:01 (UTC+8)
Abstract:	In this paper, we wish to report a facile methylation of aimple quinones as revealed by their reactions with methylcobalamin in aqueous solutions. Previous report 1) from this laboratory concerned with similar reactions but by the use of synthetic cobalt complex such as methylcobaloxime (bis (dimethylglyoximato) cobalt) in CH3OH-CH3CN solutions,where the trdnsmethylations were recognized to only a very msall extent unless some transition metal salts were added to the reaction system. In the present work, C-methylation of 1, 4-benzoquinone (BQ) as well as of 1, 4-naphthoquinone (NQ) was found to take place to 30-50 % yield without any additive at 37? in the presence of methylcobalamin (CH3-B12) in aqueous solutions.
Relation:	嘉南學報, n.1 pp.110-113 轉載
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles [Chna Nan Annual Bulletin] Vol.1 (1975)

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