Chemistry of Unsymmetrical Quarter nary Carbon Compounds Ⅲ Synthesis of (－)-Dimethyl 2-Cyano-2-Methylsuccinate and Determination of its Absolute Configuration.

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Title:	Chemistry of Unsymmetrical Quarter nary Carbon Compounds Ⅲ Synthesis of (－)-Dimethyl 2-Cyano-2-Methylsuccinate and Determination of its Absolute Configuration.
Authors:	Kong-Ko Lee
Contributors:	私立嘉南藥學專科學校
Date:	1976
Issue Date:	2014-12-25 15:03:44 (UTC+8)
Abstract:	(-)-Dimethyl 2-cyano-2-methylsuccinate ((-)-IIIa) was synthesized from menthyl cyanoacetate((-)-I), and the absolute configuration of which was elucidated as (S)-configuration by chemical correlation to the known (R)(+)-β-methylterbic acid ((R)(+)-VII). (-)-Dimethyl 2-carbanmoyl-2-methylsuccinate ((-)-IV) are also (-)-methyl 3-methyl-2, 5-dioxo-3-pyrrolidincearboxylate ((-)-V) are also confirmed as belonging to (S)-configuration and (+)-3-(1-hydroxy-1-methylethyl)-3-methyl-2, 5-prrolidineedione((+)-VI) is belonging to (R)-configuration. Preliminary experiments on racemic compounds are also described.
Relation:	嘉南學報, n.2 pp.A22-A30 轉載 Journal of the Chinese Chemical Society, v.20 n.2 pp.107-145 (1973)
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.2 (1976)

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