Tumor targeting and MR imaging with lipophilic cyanine-mediated near-infrared responsive porous Gd silicate nanoparticles

doi:10.1016/j.biomaterials.2013.04.020

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/27955

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標題:	Tumor targeting and MR imaging with lipophilic cyanine-mediated near-infrared responsive porous Gd silicate nanoparticles
作者:	Yeh, Chen-Sheng Su, Chia-Hao Ho, Wen-Yueh Huang, Chih-Chia Chang, Jui-Cheng Chien, Yi-Hsin Hung, Shu-Ting Liau, Min-Chiau Ho, Hsin-Yi Yeh, Chen-Sheng
貢獻者:	化妝品應用與管理系
關鍵字:	Lipophilic Cyanine Near-Infrared Magnetic Resonance Imaging Gd Silicate
日期:	2013-07
上傳時間:	2014-05-26 10:50:31 (UTC+8)
出版者:	Elsevier Sci Ltd
摘要:	We synthesize a NIR MHI-148 dye, a lipophilic heptamethine cyanine, with capability in tumor-targeting property to accumulate in the mitochondria of tumor. In the context of MHI-148 dye, we demonstrate effective tumor targeting and NIR fluorescence in vitro and in vivo for MHI-148 as compared to ICG. A series of porous Gd silicates related nanoparticles, i.e. Gd silicate, Gd silicate@mSiO(2) (mSiO(2): mesoporous silica shell), and Gd3+-chelated Gd silicate@mSiO(2) (Gd3+-DOTA chelated on the mSiO(2)) are fabricated to demonstrate their magnetic resonance (MR) contrast imaging effects. Those Gd silicates related nanoparticles exhibit dual MR effect, expressing T-1-brightened and T-2-darkened effects, in lower magnetic field. In high magnetic field, an abnormal enhanced transverse relaxivity (r(2)) appears, showing an effective T-2-lowering effect, possibly due to concentrated Gd amount and porous architecture. The r(2) value increases 4-5 times as the field strength increased from 3T to 7T. The Gd3+-chelated Gd silicate@mSiO(2) has given large r(2) (T-2-lowering effect) up to 343.8 s(-1) mM(-1), which is even larger than the reported magnetic Fe3O4 nanoparticles measured at the same field. Using a 9.4T animal micro MRI system we have seen effectively darken in signal for those porous Gd silicates related NPs, while no such phenomenon appears in commercial Gd-DOTA agent. The MHI-148 is then conjugated on the porous Gd silicate@mSiO(2) nanoparticles for a new paradigm with three functionalities for in vivo tumor targeting, near-infrared fluorescent and MR imaging by means of only using MHI-148 dye. (C) 2013 Elsevier Ltd. All rights reserved.
關聯:	Biomaterials, v.34 n.22, pp.5677-5688
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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