Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27932
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    標題: Suppression of Plasminogen Activators and the MMP-2/-9 Pathway by a Zanthoxylum avicennae Extract to Inhibit the HA22T Human Hepatocellular Carcinoma Cell Migration and Invasion Effects in Vitro and in Vivo via Phosphatase 2A Activation
    作者: Dung, Tran Due
    Feng, Chih-Chung
    Kuo, Wei-Wen
    Pai, Peiying
    Chung, Li-Chin
    Chang, Sheng-Huang
    Hsu, Hsi-Hsien
    Tsai, Fuu-Jen
    Lin, Yueh-Min
    Huang, Chih-Yang
    貢獻者: 醫務管理系
    關鍵字: Hepatocellular Carcinoma
    Zanthoxylum Avicennae (Ying Bu Bo)
    Protein Phosphatase 2A
    Pas And Mmp-2/-9
    Migration And Invasion
    日期: 2013-09
    上傳時間: 2014-05-26 10:49:33 (UTC+8)
    出版者: Taylor & Francis Ltd
    摘要: This study shows that the ECM degradation-associated pathway, including uPA and tPA and the downstream MMP-2/-9 protein, was significantly suppressed in HA22T cells treated with a Zanthoxylum avicennae extract (YBBE). The endogenous inhibitors, including TIMP-1/-2 and PAI-1, were enhanced in HA22T cells by the YBBE treatment. The expression of MMP-2/-9 and TIMP-1/-2 was respectively assessed by using RTPCR and a zymography assay. The mRNA levels and enzymatic activity of MMP-2/-9 were down-regulated by the YBBE treatment in a dose-dependent manner, while the TIMP-1/-2 levels were conversely markedly increased. The PP2A siRNA or PP2A inhibitor totally reversed the YBBE effects, confirming the essential role of PP2A in YBBE inhibiting the HA22T cell migration and invasion effects. Xenografted animal experiments on nude mice demonstrated similiar results to the in vitro system. Both the in vitro and in vivo models clearly demonstrate that YBBE inhibited the highly metastatic HA22T liver cancer cell migration and invasion effects through PP2A activation.
    關聯: Bioscience Biotechnology And Biochemistry, v.77 n.9, pp.1814-1821
    显示于类别:[醫務管理系(所)] 期刊論文


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