Performance of homeostasis model assessment and serum high-sensitivity C-reactive protein for prediction of isolated post-load hyperglycaemia

doi:10.1111/dme.12008

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27898

Title:	Performance of homeostasis model assessment and serum high-sensitivity C-reactive protein for prediction of isolated post-load hyperglycaemia
Authors:	Lai, Y. -C. Li, H. -Y. Hung, C. -S. Lin, M. -S. Shih, S. -R. Ma, W. -Y. Hua, C. -H. Chuang, L. -M. Sung, F. -C. Jung-Nan Wei
Keywords:	Fasting Plasma-Glucose Isolated Postchallenge Hyperglycemia Glycated Hemoglobin A1C Insulin-Resistance Diabetes-Mellitus Risk Score Complications Population Individuals Association
Date:	2013-03
Issue Date:	2014-05-26 10:48:09 (UTC+8)
Publisher:	Wiley-Blackwell
Abstract:	Diabet. Med. 30, 318325 (2013) Abstract Aims To evaluate whether homeostasis model assessment and high-sensitivity C-reactive protein improve the prediction of isolated post-load hyperglycaemia. Methods The subjects were 1458 adults without self-reported diabetes recruited between 2006 and 2010. Isolated post-load hyperglycaemia was defined as fasting plasma glucose <7mmol/l and 2-h post-load plasma glucose 11.1mmol/l. Risk scores of isolated post-load hyperglycaemia were constructed by multivariate logistic regression. An independent group (n=154) was enrolled from 2010 to 2011 to validate the models' performance. Results One hundred and twenty-three subjects (8.28%) were newly diagnosed as having diabetes mellitus. Among those with undiagnosed diabetes, 64 subjects (52%) had isolated post-load hyperglycaemia. Subjects with isolated post-load hyperglycaemia were older, more centrally obese and had higher blood pressure, HbA1c, fasting plasma glucose, triglycerides, LDL cholesterol, high-sensitivity C-reactive protein and homeostasis model assessment of insulin resistance and lower homeostasis model assessment of -cell function than those without diabetes. The risk scores included age, gender, BMI, homeostasis model assessment, high-sensitivity C-reactive protein and HbA1c. The full model had high sensitivity (84%) and specificity (87%) and area under the receiver operating characteristic curve (0.91), with a cut-off point of 23.81; validation in an independent data set showed 88% sensitivity, 77% specificity and an area under curve of 0.89. Conclusions Over half of those with undiagnosed diabetes had isolated post-load hyperglycaemia. Homeostasis model assessment and high-sensitivity C-reactive protein are useful to identify subjects with isolated post-load hyperglycaemia, with improved performance over fasting plasma glucose or HbA1c alone.
Relation:	Diabetic Medicin, v.30 n.3, pp.318-325
Appears in Collections:	[Dept. of Occupational Safety] Periodical Articles

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