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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27888

    標題: Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans
    作者: Yaegashi, Junko
    Praseuth, Mike B.
    Tyan, Shiaw-Wei
    Sanchez, James F.
    Entwistle, Ruth
    Chiang, Yi-Ming
    Oakley, Berl R.
    Wang, Clay C. C.
    貢獻者: 生物科技系
    關鍵字: Activated Protein-Kinase
    Polyketide Synthase
    Sexual Development
    Map Kinase
    日期: 2013-06
    上傳時間: 2014-05-26 10:47:45 (UTC+8)
    出版者: Amer Chemical Soc
    摘要: Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knockout library of A. nidulans was examined, and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway.
    關聯: Organic Letters, v.15 n.11, pp.2862-2865
    Appears in Collections:[生物科技系(所)] 期刊論文
    [藥學系(所)] 期刊論文

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