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標題: | Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans |
作者: | Yaegashi, Junko Praseuth, Mike B. Tyan, Shiaw-Wei Sanchez, James F. Entwistle, Ruth Chiang, Yi-Ming Oakley, Berl R. Wang, Clay C. C. |
貢獻者: | 生物科技系 藥學系 |
關鍵字: | Activated Protein-Kinase Polyketide Synthase Sexual Development Map Kinase Fungus Meroterpenoids Uncovers Product Pathway Stress |
日期: | 2013-06 |
上傳時間: | 2014-05-26 10:47:45 (UTC+8) |
出版者: | Amer Chemical Soc |
摘要: | Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knockout library of A. nidulans was examined, and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway. |
關聯: | Organic Letters, v.15 n.11, pp.2862-2865 |
顯示於類別: | [生物科技系(所)] 期刊論文 [藥學系(所)] 期刊論文
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