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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27882

    標題: Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats
    作者: Tian, Yu-Feng
    He, Chih-Tsueng
    Chen, Yu-Ting
    Hsieh, Po-Shiuan
    貢獻者: 保健營養系
    關鍵字: Lipoic Acid
    Oxidative Stress
    Portal Endotoxemia
    Insulin Secretion
    日期: 2013-05
    上傳時間: 2014-05-26 10:47:30 (UTC+8)
    出版者: Baishideng Publ Grp Co Ltd
    摘要: AIM: To examine the effect of alpha-lipoic acid (LA) on mild portal endotoxemia-induced steatohepatitis and associated pancreatic abnormalities in fructose-fed rats.METHODS: Rats were randomly assigned into two groups with a regular or 60% fructose-enriched diet for 8 wk. After fructose feeding for 4 wk, rats were further divided into four subgroups: with intraportal saline (FPV), with intraportal saline plus administration of LA (FPV + LA), with lipopolysaccharide (LPS) infusion (FPLPS), and with LPS infusion plus administration of LA (FPLPS + LA). Rats were treated with LPS using intraportal infusion while LA was administered orally. Metabolite levels, superoxide levels, inflammatory markers, malondialdehyde content, glutathione content and toll-like receptor 4 (TLR4) gene expression were all measured using standard biochemical techniques. Pancreatic insulin secretion was evaluated by a hyperglycemic clamp technique. Histology of liver and pancreas tissues were evaluated using hematoxylin and eosin staining and immunohistochemistry.RESULTS: Fructose-induced elevation in plasma C-reactive protein, amylase, superoxide, white blood cell count as well as in hepatic and pancreatic contents of malondialdehyde, tumor necrosis factor alpha and interleukin-6 were increased in animals treated with LPS and reversed with LA administration. The augmented hepatic gene expression of TLR4 in fructose-fed rats was further increased in those with intraportal LPS infusion, which was partially reversed by LA administration. Pathological examination showed inflammatory changes and leukocyte infiltration in hepatic and pancreatic islets of animals treated with LPS but were rarely observed in those with LA treatment. In addition to affects on the liver, impaired pancreatic insulin secretion seen in fructose-fed rats was deteriorated in with LPS treatment and partially reversed with LA administration.CONCLUSION: These data suggest LA could significantly suppress mild portal-endotoxemia but not fructose-induced liver and pancreatic abnormalities in a rodent model for metabolic syndrome. (C) 2013 Baishideng. All rights reserved.
    關聯: World Journal of Gastroenterology, v.19 n.18, pp.2761-2771
    Appears in Collections:[保健營養系(所) ] 期刊論文

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