English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18076/20274 (89%)
造訪人次 : 5356042      線上人數 : 1058
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/27864


    標題: Increase of Peroxisome Proliferator-activated Receptor delta (PPAR delta) by Digoxin to Improve Lipid Metabolism in the Heart of Diabetic Rats
    作者: Chen, Z. -C.
    Yu, B. -C.
    Chen, L. -J.
    Cheng, J. -T.
    貢獻者: 藥學系
    關鍵字: Cardiomyocytes
    Digoxin
    Fatty Acid Oxidation Genes
    Ppar Delta
    Sirna
    日期: 2013-05
    上傳時間: 2014-05-26 10:46:47 (UTC+8)
    出版者: Georg Thieme Verlag Kg
    摘要: Increase of peroxisome proliferator-activated receptor delta (PPAR delta) expression by digoxin in the heart of diabetic rats has been documented. The present study investigated the mediation of PPAR delta in lipid metabolism improved by digoxin in the heart of diabetic rats and in the hyperglycemia-treated cardiomyocytes using the primary cultured cardiomyocytes from neonatal rat. The lipid deposition within the heart section was assessed in diabetic rats by oil red O staining. The fatty acid oxidation genes in cardiomyocytes were also examined. Inhibitor of calcium ions and siRNA-PPAR delta were employed to investigate the potential mechanisms. After a 20-day digoxin treatment, the PPAR delta expression was elevated in hearts of diabetic rats while the cardiac lipid deposition was reduced. In neonatal cardiomyocytes, digoxin also caused an increase in expressions of PPAR delta and fatty acid oxidation genes. But both actions of digoxin were blocked by BAPTA-AM to chelate calcium ions and by siRNA-PPAR delta in cardiomyocytes. The obtained results show that increase of PPAR delta by digoxin is related to regulation of fatty acid oxidation genes in cardiac cells mediated by calcium-triggered signals.
    關聯: Hormone And Metabolic Research, v.45 n.5, pp.364-371
    顯示於類別:[藥學系(所)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML1735檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋