In vitro efficacy of fosfomycin-based combinations against clinical vancomycin-resistant Enterococcus isolates

doi:10.1016/j.diagmicrobio.2013.07.012

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Title:	In vitro efficacy of fosfomycin-based combinations against clinical vancomycin-resistant Enterococcus isolates
Authors:	Tang, Hung-Jen Chen, Chi-Chung Zhang, Chun-Cheng Su, Bo-An Li, Chien-Ming Weng, Tzu-Chieh Chiang, Shyh-Ren Ko, Wen-Chien Chuang, Yin-Ching
Contributors:	保健營養系
Keywords:	Synergistic Effect Vancomycin-Resistant Enterococci Biofilm
Date:	2013-11
Issue Date:	2014-05-26 10:46:44 (UTC+8)
Publisher:	Elsevier Science Inc
Abstract:	Vancomycin-resistant (VR) enterococci (VRE) are increasingly important nosocomial pathogens, commonly causing catheter-related urinary tract infections or vascular catheter-related bloodstream infections. In this study, 10 Enterococcus faecium and 9 Enterococcus faecalis different pulsed-field gel electrophoresis genome-type VR clinical isolates were detected. The potential role of fosfomycin-based combination regimens for biofilm-related VRE infection is in vitro evaluated. Anti-VRE activities of fosfomycin, ampicillin, linezolid, minocycline, rifampicin, tigecycline, teicoplanin, vancomycin alone, or fosfomycin-based combinations were studied by time-kill method and a biofilm model. Of the fosfomycin-based combinations, a synergistic effect was particularly noted for teicoplanin against 89% of the VR E. faecalis isolates. In a biofilm model, only linezolid alone was able to reduce the bacterial loads, and the use of fosfomycin-based combinations, excluding rifampicin (40%), failed to enhance antibacterial activity against VR E. faecium. For E. faecalis, an inhibitory effect was evident using ampicillin alone or fosfomycin plus rifampicin (100%), tigecycline (56%), or teicoplanin (44%). However, an antagonistic effect was found for ampicillin plus fosfomycin against 2 of 3 of the VR E. faecalis isolates. The antibacterial activities of the drugs tested against VRE in vitro varied by species. Ampicillin exhibited potential activity against planktonic- and biofilm-embedded VR E. faecalis. Fosfomycin-based combinations may have enhanced antibacterial effects against VRE even in the biofilm model, and this observation warrants further clinical studies. (C) 2013 Elsevier Inc. All rights reserved.
Relation:	Diagnostic Microbiology And Infectious Disease, v.77 n.3 pp.254-257
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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