Impact of head and neck malignancies on risk factors and survival in systemic lupus erythematosus

doi:10.3109/00016489.2013.800228

CNU IR > College of Smart Living > Dept. of Hospital and Health (including master's program) > Periodical Articles > Item 310902800/27858

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27858

Title:	Impact of head and neck malignancies on risk factors and survival in systemic lupus erythematosus
Authors:	Chang, Shih-Lun Hsu, Hsin-Te Weng, Shih-Feng Lin, Yung-Song
Contributors:	醫務管理系
Keywords:	Head And Neck Cancer Nasopharyngeal Carcinoma Cancer Survival Oropharyngeal Carcinoma Oral Cancer
Date:	2013-10
Issue Date:	2014-05-26 10:46:32 (UTC+8)
Publisher:	Informa Healthcare
Abstract:	Conclusions: Systemic lupus erythematosus (SLE) is associated with an increased risk of developing a head and neck malignancy (HNM). A history of SLE did not significantly impact the survival of our study cohort after cancer developed. Objectives: To examine the risk and survival rates of HNM in patients with SLE. Methods: This was a population-based, retrospective cohort study. We compared patients newly diagnosed with SLE between 2001 and 2008 (n = 8751) with age-matched controls (1: 10) (n = 87 510). The incidence of HNMs at the end of 2009 was then determined. Results: We found a 2.16-fold higher risk of HNMs in patients diagnosed with SLE compared with the risk of first malignancy in the age-matched controls (incidence rate ratio, IRR = 2.16, p < 0.05). The site with the highest incidence of HNMs in SLE patients was the oral cavity (5/11, 45.45%), followed by the nasopharynx (4/11, 36.36%). SLE displayed no synergic effect on the survival of SLE patients with an HNM compared with age-matched controls with a new HNM (p = 0.2446).
Relation:	Acta Oto-Laryngologica, v.133 n.10 pp.1088-1095
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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