Immunomodulatory Activities of Medicinal Mushroom Grifola frondosa Extract and Its Bioactive Constituent

doi:10.1142/S0192415X13500109

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/27857

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27857

Title:	Immunomodulatory Activities of Medicinal Mushroom Grifola frondosa Extract and Its Bioactive Constituent
Authors:	Wu, Shu-Jing Lu, Tzy-Ming Lai, Min-Nan Ng, Lean-Teik
Contributors:	保健營養系
Keywords:	Grifola Frondosa Medicinal Mushroom Ergosterol Peroxide Immunomodulatory Activity Pro-Inflammatory Mediators Thp-1 Cells
Date:	2013
Issue Date:	2014-05-26 10:46:30 (UTC+8)
Publisher:	World Scientific Publ Co Pte Ltd
Abstract:	Grifola frondosa (GF), a high value medicinal mushroom in China and Japan, is popularly consumed as traditional medicines and health foods, especially for enhancing immune functions. In this study, our aim was to examine the immunomodulatory activities of GF and its bioactive compound ergosterol peroxide (EPO) in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. At low concentrations, EPO but not other extracts showed a full protection against LPS-induced cell toxicity. EPO significantly blocked MyD88 and VCAM-1 expression, and cytokine (IL-1 beta, IL-6 and TNF-alpha) production in LPS-stimulated cells. It also effectively inhibited NF-kappa B activation, which was further confirmed with siRNA treatment. These results conclude that EPO may play an important role in the immunomodulatory activity of GF through inhibiting the production of pro-inflammatory mediators and activation of NF-kappa B signaling pathway.
Relation:	American Journal of Chinese Medicine, v.41 n.1, pp.131-144
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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