Extraction of protocatechuic acid from Scutellaria barbata D. Don using supercritical carbon dioxide

doi:10.1016/j.supflu.2013.04.007

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Title:	Extraction of protocatechuic acid from Scutellaria barbata D. Don using supercritical carbon dioxide
Authors:	Yang, Yu-Chiao Wei, Ming-Chi Huang, Ting-Chia Lee, Suen-Zone
Contributors:	環境工程與科學系
Keywords:	Scutellaria Barbata D. Don Protocatechuic Acid Supercritical Carbon Dioxide Extraction Ultrasound-Assisted Extraction Solubility Hplc
Date:	2013-09
Issue Date:	2014-05-26 10:46:06 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	The use of supercritical carbon dioxide (SC-CO2), with water as a modifier, was evaluated in this study as a method to extract protocatechuic acid (PA) from Scutellaria barbata D. Don. The highest extraction yield of PA, 64.094 +/- 2.756 mu g/g of dry plant, was achieved at 75 degrees C and 27.5 MPa, with the addition of 15.6% (v/v) water as a modifier. The mean particle size was 0.355 mm, the CO2 flow rate was 2.2 mL/min (STP) and the dynamic extraction time was 100 min. At pressures of 16.2-30.0 MPa and temperatures of 45-75 degrees C, the mole fraction solubilities of PA in SC-CO2 ranged from 2.829 x 10(-7) to 9.631 x 10(-7). The solubility data for PA fit well in the Chrastil model. It is evident that the SC-CO2 extraction uses less solvent, saves both energy and time and is an environmentally friendly extract technology that can be used in the food, cosmetic and pharmaceutical industries. (C) 2013 Elsevier B.V. All rights reserved.
Relation:	Journal of Supercritical Fluids, v.81, pp.55-66
Appears in Collections:	[Dept. of Environmental Engineering and Science (including master's program)] Periodical Articles

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