Effects of 1-hexadecyl-3-methylimidazolium ionic liquids on the physicochemical characteristics and cytotoxicity of phosphatidylcholine vesicles

doi:10.1016/j.colsurfa.2013.08.040

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/27832

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標題:	Effects of 1-hexadecyl-3-methylimidazolium ionic liquids on the physicochemical characteristics and cytotoxicity of phosphatidylcholine vesicles
作者:	Liang, Chia-Hua Ho, Wen-Yueh Yeh, Li-Hsien Cheng, Yu-Shen Chou, Tzung-Han
貢獻者:	化妝品應用與管理系
關鍵字:	Long Alkyl-Chain Imidazolium-Based Ionic Liquids Phosphatidylcholines Physicochemical Characteristics Vesicles Cytotoxicity Apoptotic Characteristic
日期:	2013-09
上傳時間:	2014-05-26 10:45:29 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	This report is the first to study behaviors of nano-scale colloids prepared by long alkyl-chain imidazolium-based ionic liquids (LILs), namely, 1-hexadecyl-3-methylimidazolium hexafluorophosphate (C16MIMPF6) and 1-hexadecyl-3-methylimidazolium bromide (C16MIMBr), as well as phosphatidylcholines (PCs), including hydrogenated soybean phosphatidylcholine (HSPC) and egg phosphatidylcholine (EPC). The effects of LILs on the physicochemical characteristics of PC vesicles are investigated using morphological observations and measurements of particle size, zeta potential, and fluorescence polarization. The experimental data reveal that the incorporation of LILs into PC vesicles shows significant changes in the size, turbidity, zeta potential, storage stability, and membrane fluidity of colloids, which may be correlated with the counter-ions of the LILs, the degree of saturation of the PCs, and the vesicular composition. In addition, the cell viability of HaCaT. A431, and SCC25 cells decreases in a dose-dependent manner and is associated with the composition of the PC vesicles that are incorporated with LIL. The apoptotic characteristic of cells is more significant for the PC vesicles that incorporate a higher molar ratio of LILs at dispersion concentrations of 0.1 and 1 mM. This work suggests that cytotoxicity is dependent on the counter-ions of LILs, the composition and concentration of dispersions, and the physicochemical properties of mixed LIL/PC colloids. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
關聯:	Colloids And Surfaces A-Physicochemical And Engineering Aspects, v.436 pp.1083-1091
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