Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters

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標題:	Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters
作者:	Lee, Kuan-Han Lin, Yu-Sheng Huang, Po-Jui
貢獻者:	藥學系
關鍵字:	Self-Assembled Monolayers Alkanethiolate Monolayers Nanoparticles Core Nanocrystals Molecules Dynamics Colloids Therapy Size
日期:	2013
上傳時間:	2014-05-26 10:45:04 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	A series of new thiol-derivatized ibuprofen monolayer protected gold clusters have been prepared by amidation of ibuprofen with alkyl alcohol or aminophenol affording the carboxamides, N-hydroxyalkyl amide 2, and N-hydroxyphenyl amide 6, which were then tosylated with p-toluenesulfonyl chloride at hydroxyl group to give 3 and 7. Reactions of 3 and 7 with NaSH afforded the mercapto derivatives 4 and 8. Conducting Brust's reaction with a 3 : 1 mole ratio of thiolate ibuprofen/AuCl4- yielded polydisperse thiol-derivatized ibuprofen-MPCs 5 and 9. All compounds have been identified by NMR, MS, UV, and IR spectroscopies. Compounds 4 and 8 and the MPCs 5 and 9 have been investigated by using the method of H-1 NMR spectroscopy. The broadening of the signals from 0.8 to 2.0 ppm in H-1 NMR spectrum of MPCs 5 and 9 confirmed the success of the conjugation of thiol-containing derivatives with nanogold cluster.
關聯:	Journal of Nanomaterials v. n. pp.931815-
顯示於類別:	[Dept. of Pharmacy] Periodical Articles

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