Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells

doi:10.1016/j.jff.2013.01.020

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標題:	Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells
作者:	Hu, Te-Yu Liu, Cheng-Ling Chen, Jen-Yin Hu, Miao-Lin
貢獻者:	老人服務事業管理系
關鍵字:	Methylglyoxal Advanced Glycation End Products Curcumin Huvecs
日期:	2013-04
上傳時間:	2014-05-26 10:44:48 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	Endothelial dysfunction such as hyperpermeability is one of the characteristics in an early stage of diabetic complications. Curcumin has been shown to inhibit the formation of advanced glycation end products (AGEs) and to trap methyglyoxal (MGO) in cell-free system and in human umbilical vein endothelial cells (HUVECs). Here, we investigated the effect of curcumin on dysfunctions of HUVECs induced by exogenous MGO (30 mu M), which significantly increased intracellular reactive oxygen species (ROS), endothelial permeability, and cytoskeleton rearrangement. In contrast, MOO decreased gap junctional intercellular communication and the expression of connexin 43 and zonula occludens. Pre-treatment of HUVECs with curcumin (0.25-2.5 mu M) significantly ameliorated MGO-induced endothelial dysfunction, whereas pre-treatment with vitamin E (10 mu M) only slightly ameliorated MGO-induced endothelial dysfunction, suggesting that ROS induced by MGO do not play a major role in endothelial dysfunction. These results suggest that curcumin is a potential protective agent against MGO-induced endothelial dysfunction. (C) 2013 Elsevier Ltd. All rights reserved.
關聯:	Journal of Functional Foods, v.5 n.2 pp.745-754
顯示於類別:	[高齡福祉養生管理系] 期刊論文

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