English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17778/20119 (88%)
Visitors : 12233805      Online Users : 293
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27815

    標題: Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells
    作者: Hu, Te-Yu
    Liu, Cheng-Ling
    Chen, Jen-Yin
    Hu, Miao-Lin
    貢獻者: 老人服務事業管理系
    關鍵字: Methylglyoxal
    Advanced Glycation End Products
    日期: 2013-04
    上傳時間: 2014-05-26 10:44:48 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: Endothelial dysfunction such as hyperpermeability is one of the characteristics in an early stage of diabetic complications. Curcumin has been shown to inhibit the formation of advanced glycation end products (AGEs) and to trap methyglyoxal (MGO) in cell-free system and in human umbilical vein endothelial cells (HUVECs). Here, we investigated the effect of curcumin on dysfunctions of HUVECs induced by exogenous MGO (30 mu M), which significantly increased intracellular reactive oxygen species (ROS), endothelial permeability, and cytoskeleton rearrangement. In contrast, MOO decreased gap junctional intercellular communication and the expression of connexin 43 and zonula occludens. Pre-treatment of HUVECs with curcumin (0.25-2.5 mu M) significantly ameliorated MGO-induced endothelial dysfunction, whereas pre-treatment with vitamin E (10 mu M) only slightly ameliorated MGO-induced endothelial dysfunction, suggesting that ROS induced by MGO do not play a major role in endothelial dysfunction. These results suggest that curcumin is a potential protective agent against MGO-induced endothelial dysfunction. (C) 2013 Elsevier Ltd. All rights reserved.
    關聯: Journal of Functional Foods, v.5 n.2 pp.745-754
    Appears in Collections:[老人服務事業管理系] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback