Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27810
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    標題: Comparison of the behavioral effects of bupropion and psychostimulants
    作者: Mori, Tomohisa
    Shibasaki, Masahiro
    Ogawa, Yuki
    Hokazono, Mayuna
    Wang, Tzu-Chueh
    Rahmadi, Mahardian
    Suzuki, Tsutomu
    貢獻者: 藥學系
    關鍵字: Rewarding Effect
    Sensitization
    Bupropion
    Methamphetamine
    Dopamine
    日期: 2013-10
    上傳時間: 2014-05-26 10:44:36 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: Psychostimulant abuse has been a serious social problem worldwide for a long Lime. Bupropion, which is used as an antidepressant and to aid smoking cessation in the US, is considered to have psychostimulantlike activity. Although activation of the dopaminergic system induces several behavioral effects and bupropion can activate the dopaminergic system, the abuse potential and other behavioral effects of bupropion have not been fully investigated. Therefore, in this study we compared the behavioral effects of bupropion to those of psychostimulants in mice. Both methamphetamine and bupropion induced sensitization to locomotor activity, and cross-sensitized each other. Methamphetamine and bupropion also induced robust rewarding effects as measured by the conditioned place preference paradigm, although the conditioned reward with bupropion extinguished faster than that with methamphetamine. Furthermore, unlike psychostimulants, bupropion did not disrupt prepulse inhibition, even in bupropion-sensitized mice. These Findings constitute evidence that bupropion and methamphetamine haw similar pharmacological profiles, particularly with regard to dopamine-related behaviors. However, bupropion has lower abuse potential and side effects than methamphetamine. (C) 2013 Elsevier B.V. All rights reserved.
    關聯: European Journal of Pharmacology, v.718 n.41277 pp.370-375
    显示于类别:[藥學系(所)] 期刊論文

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