An attempt was made in this study to extract baicalin and baicalein from Radix Scutellariae using modified ultrasound-assisted extraction (UAE), and these results were compared to a commonly used heat reflux extraction (HRE) procedure. The best results were obtained when working at an ultrasonic frequency of 40 kHz, a power of 185W, an ultrasound cycle of 79% (intermittent sonication), a mean particle size of 0.355 mm, a ratio of solvent to raw material of 10:1 (mL/g), an extraction time of 20 min and three cycles. The optimum extraction temperature and ethanol concentration differ for different flavanone compounds. The extraction of baicalin and baicalein were most efficient at temperatures of 60 and 30 degrees C, respectively, with ethanol concentrations of 40 and 50% (v/v), respectively. Compared with HRE, the modified UAE method reduced the extraction time, the extraction temperature and the solvent consumption. Moreover, UAE achieved superior baicalin and baicalein yields, is a potential method for industry. (c) 2012 Elsevier B.V. All rights reserved.