Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia

doi:10.1155/2013/494179

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/27792

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27792

Title:	Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia
Authors:	Hung, Ching-Hsia Chang, Che-Ning Chen, Yu-Wen Chen, Yu-Chung Tzeng, Jann-Inn Wang, Jhi-Joung
Contributors:	食品科技系
Keywords:	Acute Lung Injury Renin-Angiotensin System Induced Lethal Toxicity Tumor-Necrosis-Factor Septic Shock Nitric-Oxide Arterial-Pressure Lipopolysaccharide Mellitus Insulin
Date:	2013
Issue Date:	2014-05-26 10:43:52 (UTC+8)
Publisher:	Hindawi Publishing Corporation
Abstract:	This study was designed to determine the severity of cardiopulmonary dysfunction during systemic endotoxemia in type 1 diabetes. Thirty-two adult male Wistar rats were randomly assigned to a control group or to a group treated with streptozotocin (STZ) to create an animal model of type 1 diabetes. Survival time and cardiovascular parameters were continually monitored in urethane anaesthetized animals receiving intravenous infusion of endotoxin (lipopolysaccharide (LPS)) or saline. We also determined arterial blood gases, lung injury, and tumor necrosis factor-alpha (TNF-alpha) levels in serum and bronchoalveolar lavage fluid. Before LPS administration, the mean arterial pressure in STZ rats was significantly higher than that in normal rats. After LPS injection, the heart rate drop significantly in STZ rats than that in the control group. Also, the increased levels of TNF-alpha in serum and lavage fluid after LPS treatment were significantly higher in STZ rats than those in normal rats. Survival time in STZ rats was shorter than that in normal rats after LPS application. Albumin content, wet/dry weight ratio of lung, and lung injury were indistinguishable between STZ and normal rats. These results indicate that the cardiopulmonary change which occurs during LPS-induced endotoxemia is minor in STZ-induced diabetic rats.
Relation:	Journal of Diabetes Research v. n. pp.494179-
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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