Application of an Efficient Gene Targeting System Linking Secondary Metabolites to their Biosynthetic Genes in Aspergillus terreus

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题名:	Application of an Efficient Gene Targeting System Linking Secondary Metabolites to their Biosynthetic Genes in Aspergillus terreus
作者:	Guo, Chun-Jun Knox, Benjamin P. Sanchez, James F. Chiang, Yi-Ming Bruno, Kenneth S. Wang, Clay C. C.
贡献者:	藥學系
关键词:	Cluster Identification Products
日期:	2013-07
上传时间:	2014-05-26 10:43:18 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Nonribosomal peptides (NRPs) are natural products biosynthesized by NRP synthetases. A kusA-, pyrG- mutant strain of Aspergillus terreus NIH 2624 was developed that greatly facilitated the gene targeting efficiency in this organism. Application of this tool allowed us to link four major types of NRP-related secondary metabolites to their responsible genes in A. terreus. In addition, an NRP affecting melanin synthesis was also identified in this species.
關聯:	Organic Letters, v.15 n.14 pp.3562-3565
显示于类别:	[Dept. of Pharmacy] Periodical Articles

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