Abdominal Obesity Is Associated with Peripheral Artery Disease in Hemodialysis Patients

doi:10.1371/journal.pone.0067555

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Title:	Abdominal Obesity Is Associated with Peripheral Artery Disease in Hemodialysis Patients
Authors:	Hung, Peir-Haur Tsai, Hung-Bin Lin, Chien-Hung Hung, Kuan-Yu
Contributors:	生活應用與保健系
Keywords:	C-Reactive Protein Stage Renal-Disease Coronary-Heart-Disease Chronic Kidney-Disease Blood-Pressure Index Treatment Panel-Iii Metabolic Syndrome Cardiovascular Mortality Inflammatory Markers Occlusive Disease
Date:	2013-06
Issue Date:	2014-05-26 10:42:45 (UTC+8)
Publisher:	Public Library Science
Abstract:	Background: Peripheral arterial disease (PAD) is a leading cause of morbidity in hemodialysis (HD) patients. Recent evidence suggests that abdominal obesity (AO) may play a role in PAD. However, the association between AO and PAD has not been thoroughly studied in HD patients.Methods: The present cross-sectional study aimed to examine the relationship between AO and PAD in a cohort of 204 chronic HD patients. The ankle brachial index (ABI) was used as an estimate of the presence of PAD. Plasma adiponectin levels, interleukin-6 (IL-6) levels, high sensitivity C-reactive protein (hs-CRP) levels, asymmetric dimethylarginine (ADMA) levels, and lipid profiles were measured. Logistic regression was used to estimate the association between the presence of PAD and AO as well as other potential risk factors.Results: The metabolic risk factors and all individual traits, including elevated ln-transformed hs-CRP, were found to be significant (P<0.05) more frequently in HD patients with AO than that in control subjects. Patients with AO had a higher prevalence of PAD than the control individuals, with a mean ABI of 0.96 +/- 0.23 and 1.08 +/- 0.16 (P<0.0001) and PAD prevalence of 26.9% and 10.8% (P=0.003), respectively. By multivariate analysis, AO (odds ratio [OR], 4.532; 95% CI, 1.765-11.639; P=0.002), elevated serum ln-transformed ADMA (OR, 5.535; 95% CI, 1.323-23.155; P=0.019), and ln-transformed IL-6 (OR, 1.567; 95% CI, 1.033-2.378; P=0.035) were independent predictors of the presence of PAD.Conclusions: HD patients with AO exhibited a cluster of metabolic risk factors and lower ABI. AO, elevated serum lntransformed ADMA, and ln-transformed IL-6 were independent predictors of the presence of PAD.
Relation:	Plos One, v.8 n.6 pp.e67555
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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