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| 標題: | Elevation of tissue alpha-tocopherol levels by conjugated linoleic acid in C57BL/6J mice is not associated with changes in vitamin E absorption or alpha-carboxyethyl hydroxychroman production |
| 作者: | Chen, Wan-Hsuan
Li, Yi-Jen
Wang, Ming-Shyong
Kang, Zhi-Chyang
Huang, Huei-Ling
Shaw, Huey-Mei |
| 貢獻者: | 保健營養系 |
| 關鍵字: | Conjugated Linoleic Acid
Alpha-Tocopherol
Alpha-Carboxyethyl Hydroxychroman
Alpha-Tocopherol Transfer Protein
Antioxidant Enzyme |
| 日期: | 2012 |
| 上傳時間: | 2014-03-24 15:22:59 (UTC+8) |
| 出版者: | Elsevier Science |
| 摘要: | Objective: Conjugated linoleic acid (CLA) decreases adipose mass and increases vitamin E levels in the liver and adipose tissue in mice. The aim of the present study was to examine the mechanism by which CLA alters vitamin E levels in tissues and antioxidant activity in mice.Methods: C57BL/6J mice were divided into three groups and fed 5% lipid as soybean oil alone (control group), 4% soybean oil supplemented with 1% CLA (CLA group), or 5% lipid with a vitamin E supplement (VE group) for 4 wk.Results: The CLA and VE diets resulted in a significant increase in the alpha-tocopherol concentration in all tissues examined, i.e., the liver, kidney, testis, spleen, heart, lung, and adipose tissue (P < 0.05). Levels of thiobarbituric acid-reactive substances in the kidney, testis, heart, lung, and adipose tissue were lower in the CLA and VE groups than in the control group (P < 0.05). CLA did not alter the absorption rate of vitamin E or alpha-carboxyethyl hydroxychromans levels in the liver and plasma. The CLA diet induced a significant increase in alpha-tocopherol transfer protein and mRNA levels in the liver. CLA resulted in a decrease in catalase and glutathione peroxidase activities and peroxisome proliferator a mRNA levels but had no effect on levels of mRNAs for other nuclear transcription factors in the liver.Conclusion: The increase in vitamin E status in CLA-fed mice is not due to altered absorption and metabolism of vitamin E but might be related to the induction of alpha-tocopherol transfer protein expression in the liver. The regulation of the activities of catalase and glutathione peroxidase by CLA is not mediated by vitamin E accumulation in the liver. (C) 2012 Elsevier Inc. All rights reserved. |
| 關聯: | Nutrition, 28(1), 59-66 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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