Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus

doi:10.1155/2012/743107

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標題:	Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus
作者:	Kan, Wei-Chih Wang, Hsien-Yi Chien, Chih-Chiang Li, Shun-Lai Chen, Yu-Chun Chang, Liang-Hao Cheng, Chia-Hui Tsai, Wan-Chen Hwang, Jyh-Chang Su, Shih-Bin Huang, Li-Hsueh Chuu, Jiunn-Jye
貢獻者:	運動管理系
關鍵字:	Anti-Hyperglycemic Activity Insulin-Resistance Syndrome Inbred Mouse Strains Beta-Cell Function Na+-K+-Atpase Hypoglycemic Activity Rodent Models Ppar-Gamma Rats Streptozotocin
日期:	2012
上傳時間:	2014-03-24 15:22:36 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	Diabetes mellitus is the most common chronic disease in the world, and a wide range of drugs, including Chinese herbs, have been evaluated for the treatment of associated metabolic disorders. This study investigated the potential hypoglycemic and renoprotective effects of an extract from the solid-state fermented mycelium of Cordyceps sinensis (CS). We employed the KK/HIJ diabetic mouse model, in which the mice were provided with a high-fat diet for 8 weeks to induce hyperglycemia, followed by the administration of CS or rosiglitazone for 4 consecutive weeks. Several parameters were evaluated, including changes in body weight, plasma lipid profiles, oral glucose tolerance tests, insulin tolerance tests, and plasma insulin concentrations. Our results show that the CS extract significantly elevated HDL/LDL ratios at 4 weeks and decreased body weight gain at 8 weeks. Interestingly, CS treatment did not lead to obvious improvements in hyperglycemia or resistance to insulin, while in vitro MTT assays indicated that CS protects pancreatic beta cells against the toxic effects of STZ. CS also enhanced renal NKA activity and reduced the accumulation of mesangial matrix and collagen deposition. In conclusion, CS extract can potentially preserve beta-cell function and offer renoprotection, which may afford a promising therapy for DM.
關聯:	Evidence-Based Complementary And Alternative Medicine, 743107,10 pages
显示于类别:	[運動管理系] 期刊論文

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