English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18034/20233 (89%)
造訪人次 : 23359024      線上人數 : 413
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/27712


    標題: Identification of bioactive compounds and comparison of apoptosis induction of three varieties of sugarcane leaves
    作者: Lee, Chia-Pu
    Chen, Zong-Tsi
    Yu, Pei-Ying
    Wang, Yin-Chuan
    Duh, Pin-Der
    貢獻者: 食品科技系
    醫藥化學系
    生物科技系
    保健營養系
    關鍵字: Antiproliferation
    Apoptosis
    Hepg2 Cell
    Sugarcane Leaves
    Reactive Oxygen Species
    Phenolic Compounds
    日期: 2012-01
    上傳時間: 2014-03-24 15:22:25 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: This study identified bioactive compounds and systematically compared apoptosis induction of water extracts of sugarcane (Saccharum officinarim L.) leaves among three varieties, including 28NG256, wild type and ROC10, using hepatoma HepG2 cell line. 28NG256 showed the highest levels of total phenolic compounds, flavonoids, tannin, ascorbic acid, and chlorogenic acid among the three varieties. Especially, 28NG256 contained a high level of caffeic acid, which was not detectable in other varieties. The cell proliferation was inhibited by 67.29%, 55.01% and 21.38% for 28NG-256, wild type and ROC10 at 1500 mu g/ml, respectively, compared to the untreated cells. The apoptosis induced by the extracts was associated with the attenuation of mitochondrial membrane potentials (Delta psi(m)), increase in Bax/Bcl-2 ratio and induction of caspase-3 activation. Of the three varieties, 28NG256 displayed the highest induction of apoptosis in HepG2 cells and the highest increase of ROS generation, suggesting that ROS play a key role in the induction of apoptosis in HepG2 cells. Based on HPLC analysis, caffeic, chlorogenic, and hydroxybenzoic acids were present in 28NG256, which may be, in part, responsible for the effect on HepG2 cell proliferation. Overall, among three varieties, 28NG256 appeared to exert the most potent inhibitory effects on the growth of HepG2 cells. (C) 2012 Elsevier Ltd. All rights reserved.
    關聯: Journal of Functional Foods, 4(1), 391-397
    顯示於類別:[ 食品科技系 ] 期刊論文
    [食藥產業暨檢測科技系(含五專)] 期刊論文
    [生物科技系(所)] 期刊論文
    [保健營養系(所) ] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML2302檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋