Hepatoprotection of emodin and Polygonum multiflorum against CCl4-induced liver injury

doi:10.3109/13880209.2011.604335

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 食品科技系 > 期刊論文 > Item 310902800/27682

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標題:	Hepatoprotection of emodin and Polygonum multiflorum against CCl4-induced liver injury
作者:	Lee, Bao-Hong Huang, Ya-Yin Duh, Pin-Der Wu, She-Ching
貢獻者:	食品科技系
關鍵字:	Polygonum Multiflorum Carbon Tetrachloride Liver Injury Emodin Inflammation
日期:	2012-03
上傳時間:	2014-03-21 16:17:31 (UTC+8)
出版者:	Informa Healthcare
摘要:	Context: Polygonum multiflorum is known as a medicinal plant. It has been used as a folk medicine which showed antioxidative property.Objective: Protective effects of the water extracts (w/v:1/10) from fresh P. multiflorum (WEP) on carbon tetrachloride (CCl4)-induced liver damage in rats were investigated.Materials and methods: CCl4 was used for inducing liver damage of SD rats, and WEP and emodin were fed for eight consecutive weeks.Results: We found that emodin levels in fresh WEP was higher than that in ripening WEP. Rats were administered WEP and emodin, the main active compound, for 56 consecutive days. WEP significantly lowered the serum levels of hepatic enzyme markers, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and reduced the generation of malonaldehyde. Treatment with WEP recovered glutathione S-transferase and catalase activity in rats as compared to treatment with CCl4 alone. In addition, serum tumor necrosis factor-alpha, an inflammatory marker, was found to decrease in rats treated with WEP. In histopathological evaluation, fatty degeneration and necrosis were found to be significantly decreased in the CCl4 plus WEP treatment group.Discussion and conclusion: WEP may be effective in attenuating liver damage by reducing lipid peroxidation as well as by positively modulating inflammation.
關聯:	Pharmaceutical Biology, 50(3), 351-359
显示于类别:	[ 食品科技系 ] 期刊論文

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