Molecular Packing and Lateral Interactions of Distearoylphosphatidylcholine with Dihexadecyldimethylammonium Bromide in Langmuir Monolayers and Vesicles

doi:10.1021/jp211264h

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/27680

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Title:	Molecular Packing and Lateral Interactions of Distearoylphosphatidylcholine with Dihexadecyldimethylammonium Bromide in Langmuir Monolayers and Vesicles
Authors:	Chang, Chien-Hsiang Liang, Chia-Hua Hsieh, Yu-Ying Chou, Tzung-Han
Contributors:	化妝品應用與管理系
Keywords:	Air-Water-Interface Cationic Liposomes Transfection Efficiency Air/Water Interface Surfactant Systems Lipid Interactions Gene Transfection Phase-Transitions Synthetic Lipids Membrane
Date:	2012-03
Issue Date:	2014-03-21 16:17:27 (UTC+8)
Publisher:	Amer Chemical Soc
Abstract:	The behavior of distearoylphosphatidylcholine (DSPC) mixed with dihexadecyldimethylammonium bromide (DHDAB) in the monolayer was investigated by means of Langmuir trough, interfacial thermodynamic analysis, and Brewster angle microscopy. It was found that the cationic surfactant, DHDAB, was miscible with DSPC and a condensing effect, indicating stronger contraction of area per molecule and stronger ordering molecular packing, appeared in the mixed DSPC/DHDAB monolayers. Condensed structures of the mixed monolayers were visible as the molar fraction of DHDAB (X-DHDAB) <= 0.7. The negative deviations of excess area and mixing Gibbs free energy were obtained, and their minimum values occurred at X-DHDAB = 0.3, suggesting that a DSPC/DHDAB monolayer with this composition exhibited the most pronounced intermolecular interactions with a compact molecular arrangement than the monolayers with separation between individual components. Furthermore, characteristics of mixed DSPC/DHDAB vesicles dispersed in water were studied by dynamic light scattering, transmission electron microscopy, and fluorescence polarization. The DSPC vesicles added with DHDAB showed zeta potentials of about +50 mV and narrower size distributions than those of pure DSPC vesicles. DSPC formed more rigid membranes than DHDAB, and the minimum disordering effect on membrane packing of vesicles was found at X-DHDAB = 0.5, which was the most stable vesicle composition against aggregation. By contrast, the condensing effect and the increase of intermolecular attraction in mixed DSPC/DHDAB monolayers may be related to the stability enhancement of mixed vesicles as compared with the stability of pure component vesicles.
Relation:	Journal of Physical Chemistry B, 116(8), 2455-2463
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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