Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

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標題:	Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans
作者:	Ahuja, Manmeet Chiang, Yi-Ming Chang, Shu-Lin Praseuth, Mike B. Entwistle, Ruth Sanchez, James F. Lo, Hsien-Chun Yeh, Hsu-Hua Oakley, Berl R. Wang, Clay C.C.
貢獻者:	藥學系
關鍵字:	Gene-Cluster Biosynthetic-Pathway Acid Synthase Identification Meroterpenoids Product Naphthopyrone Thioesterase Metabolites Cyclization
日期:	2012-05-16
上傳時間:	2014-03-21 16:16:24 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP biosynthetic pathways, and other genes necessary for NR-PKS product formation or release. This has allowed us to determine the products of eight NR-PKSs of Aspergillus nidulans, including seven novel compounds, as well as the NR-PKS genes required for the synthesis of the toxins alternariol (8) and cichorine (19).
關聯:	Journal of The American Chemical Society, 134(19), 8212-8221
顯示於類別:	[藥學系(所)] 期刊論文

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