Antimicrobial susceptibility profiles of Gram-negative bacilli isolated from patients with hepatobiliary infections in Taiwan: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2006-2010

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標題:	Antimicrobial susceptibility profiles of Gram-negative bacilli isolated from patients with hepatobiliary infections in Taiwan: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2006-2010
作者:	Toh, Han-Siong Chuang, Yin-Ching Huang, Chi-Chang Lee, Yu-Lin Liu, Yuag-Meng Ho, Cheng-Mao Lu, Po-Liang Liu, Chun-Eng Chen, Yen-Hsu Wang, Jen-Hsien Ko, Wen-Chien Yu, Kwok-Woon Liu, Yung-Ching Chen, Yao-Shen Tang, Hung-Jen Hsueh, Po-Ren
貢獻者:	保健營養系
關鍵字:	Study For Monitoring Antimicrobial Resistance Trends Enterobacteriaceae Hepatobiliary Tract Infections Gram-Negative Bacilli
日期:	2012-06
上傳時間:	2014-03-21 16:15:59 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	We investigated the trends in antimicrobial resistance among species of Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan during the period 20062010 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, 1032 isolates of Gram-negative bacilli that had been collected from patients with hepatobiliary infections were tested for susceptibility to 12 antimicrobial agents in accordance with the Clinical and Laboratory Standards Institute guidelines. Enterobacteriaceae accounted for the majority (n = 874, 84.7%) of isolates and Escherichia coli was the most common pathogen (n = 323, 31.3%). There were significantly more E. coli (P = 0.001) and Proteus mirabilis (P = 0.031) isolates collected from patients who had been hospitalized for less than 48 h and significantly more Serratia marcescens (P = 0.035) and Pseudomonas aeruginosa (P = 0.008) isolates collected from patients who had been hospitalized for 48 h or longer. The prevalence of extended-spectrum beta-lactamase (ESBL)-producing pathogens was low. The decline in susceptibility rates with time was remarkable for ceftazidime (P = 0.036), ciprofloxacin (P = 0.029), and levofloxacin (P = 0.018). The most effective antibiotics, i.e., those that were active against more than 90% of Enterobacteriaceae, were amikacin, cefepime, imipenem, ertapenem, and piperacillin-tazobactam. Susceptibility of P. aeruginosa to anti-pseudomonal agents was greater than 80%. In this study, we found an overall increase in resistance to antimicrobial agents among Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan. Surveillance of antimicrobial susceptibility and updates of treatment guidelines are recommended to help achieve optimal therapy for patients with hepatobiliary infections. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
關聯:	International Journal of Antimicrobial Agents, 40 S1, S18-S23
顯示於類別:	[保健營養系(所) ] 期刊論文

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