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| 標題: | Antimicrobial susceptibility profiles of Gram-negative bacilli isolated from patients with hepatobiliary infections in Taiwan: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2006-2010 |
| 作者: | Toh, Han-Siong
Chuang, Yin-Ching
Huang, Chi-Chang
Lee, Yu-Lin
Liu, Yuag-Meng
Ho, Cheng-Mao
Lu, Po-Liang
Liu, Chun-Eng
Chen, Yen-Hsu
Wang, Jen-Hsien
Ko, Wen-Chien
Yu, Kwok-Woon
Liu, Yung-Ching
Chen, Yao-Shen
Tang, Hung-Jen
Hsueh, Po-Ren |
| 貢獻者: | 保健營養系 |
| 關鍵字: | Study For Monitoring Antimicrobial Resistance Trends
Enterobacteriaceae
Hepatobiliary Tract Infections
Gram-Negative Bacilli |
| 日期: | 2012-06 |
| 上傳時間: | 2014-03-21 16:15:59 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | We investigated the trends in antimicrobial resistance among species of Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan during the period 20062010 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, 1032 isolates of Gram-negative bacilli that had been collected from patients with hepatobiliary infections were tested for susceptibility to 12 antimicrobial agents in accordance with the Clinical and Laboratory Standards Institute guidelines. Enterobacteriaceae accounted for the majority (n = 874, 84.7%) of isolates and Escherichia coli was the most common pathogen (n = 323, 31.3%). There were significantly more E. coli (P = 0.001) and Proteus mirabilis (P = 0.031) isolates collected from patients who had been hospitalized for less than 48 h and significantly more Serratia marcescens (P = 0.035) and Pseudomonas aeruginosa (P = 0.008) isolates collected from patients who had been hospitalized for 48 h or longer. The prevalence of extended-spectrum beta-lactamase (ESBL)-producing pathogens was low. The decline in susceptibility rates with time was remarkable for ceftazidime (P = 0.036), ciprofloxacin (P = 0.029), and levofloxacin (P = 0.018). The most effective antibiotics, i.e., those that were active against more than 90% of Enterobacteriaceae, were amikacin, cefepime, imipenem, ertapenem, and piperacillin-tazobactam. Susceptibility of P. aeruginosa to anti-pseudomonal agents was greater than 80%. In this study, we found an overall increase in resistance to antimicrobial agents among Gram-negative bacilli isolated from patients with hepatobiliary tract infections in Taiwan. Surveillance of antimicrobial susceptibility and updates of treatment guidelines are recommended to help achieve optimal therapy for patients with hepatobiliary infections. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved. |
| 關聯: | International Journal of Antimicrobial Agents, 40 S1, S18-S23 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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