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| 標題: | Impact of revised CLSI breakpoints for susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2002-2010 |
| 作者: | Huang, Chi-Chang
Chen, Yao-Shen
Toh, Han-Siong
Lee, Yu-Lin
Liu, Yuag-Meng
Ho, Cheng-Mao
Lu, Po-Liang
Liu, Chun-Eng
Chen, Yen-Hsu
Wang, Jen-Hsien
Tang, Hung-Jen
Yu, Kwok-Woon
Liu, Yung-Ching
Chuang, Yin-Ching
Xu, Yingchun
Ni, Yuxing
Ko, Wen-Chien
Hsueh, Po-Ren |
| 貢獻者: | 保健營養系 |
| 關鍵字: | Intra-Abdominal Infections
Enterobacteriaceae
Extended-Spectrum Beta-Lactamase
Cephalosporins
Carbapenems |
| 日期: | 2012-06 |
| 上傳時間: | 2014-03-21 16:15:51 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | This study examined the rates of susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates that had been obtained from patients with intra-abdominal infections in the Asia-Pacific region as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). Susceptibility profiles obtained using 2009 Clinical and Laboratory Standards Institute (CLSI) breakpoints were compared with those obtained using the 2011 CLSI breakpoints. From 2002 to 2010, Escherichia coli and Klebsiella pneumoniae together accounted for more than 60% of the 13714 Enterobacteriaceae isolates analyzed during the study period. Extended-spectrum beta-lactamase (ESBL) producers comprised 28.2% of E. coli isolates and 22.1% of K. pneumoniae isolates in the Asia-Pacific region, with China (55.6% and 33.7%, respectively) and Thailand (43.1% and 40.7%, respectively) having the highest proportions of ESBL producers. Based on the 2011 CLSI criteria, 77.2% of the Enterobacteriaceae isolates, 40.4% of ESBL-producing E. coli, and 25.2% of ESBL-producing K. pneumoniae isolates were susceptible to ceftazidime. Carbapenems showed in vitro activity against >90% of Enterobacteriaceae isolates in all participating countries, except for ertapenem in South Korea (susceptibility rate 82.2%). Marked differences (>5%) in susceptibility of ESBL-producing E. coli and K. pneumoniae isolates to carbapenems were noted between the profiles obtained using the 2009 CLSI criteria and those using the 2011 CLSI criteria. Continuous monitoring of antimicrobial resistance is necessary in the Asia-Pacific region. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved. |
| 關聯: | International Journal of Antimicrobial Agents v.40 S1 pp.S4-S10 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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