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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27630

    標題: Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010
    作者: Ho, Cheng-Mao
    Ho, Mao-Wang
    Liu, Yung-Ching
    Toh, Han-Siong
    Lee, Yu-Lin
    Liu, Yuag-Meng
    Huang, Chi-Chang
    Lug, Po-Liang
    Liu, Chun-Eng
    Chen, Yen-Hsu
    Ko, Wen-Chien
    Tang, Hung-Jen
    Yu, Kwok-Woon
    Chen, Yao-Shen
    Chuang, Yin-Ching
    Wang, Jen-Hsien
    Hsueh, Po-Ren
    貢獻者: 保健營養系
    關鍵字: Enterobacteriaceae
    Intra-Abdominal Infections
    Carbapenem Resistance
    Carbapenem Consumption
    日期: 2012-06
    上傳時間: 2014-03-21 16:15:49 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of non-susceptibility ranged from 3.5% to 10.3% and those for imipenem ranged from 3.5% to 10.7%. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
    關聯: International Journal of Antimicrobial Agents, 40 S1, S24-S28
    Appears in Collections:[保健營養系(所) ] 期刊論文

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