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| 標題: | Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010 |
| 作者: | Ho, Cheng-Mao
Ho, Mao-Wang
Liu, Yung-Ching
Toh, Han-Siong
Lee, Yu-Lin
Liu, Yuag-Meng
Huang, Chi-Chang
Lug, Po-Liang
Liu, Chun-Eng
Chen, Yen-Hsu
Ko, Wen-Chien
Tang, Hung-Jen
Yu, Kwok-Woon
Chen, Yao-Shen
Chuang, Yin-Ching
Wang, Jen-Hsien
Hsueh, Po-Ren |
| 貢獻者: | 保健營養系 |
| 關鍵字: | Enterobacteriaceae
Intra-Abdominal Infections
Carbapenem Resistance
Carbapenem Consumption
Smart |
| 日期: | 2012-06 |
| 上傳時間: | 2014-03-21 16:15:49 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of non-susceptibility ranged from 3.5% to 10.3% and those for imipenem ranged from 3.5% to 10.7%. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved. |
| 關聯: | International Journal of Antimicrobial Agents, 40 S1, S24-S28 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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